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PIN is more common in men with prostate cancer. High grade PIN can be found in 85 to 100% of radical prostatectomy specimens, [4] nearby or even in connection with prostate cancer. It tends to occur in the peripheral zone of the prostate. With age, it becomes increasingly multifocal, like prostate cancer. Molecular analysis has shown that high ...
Prostate cancer is the uncontrolled growth of cells in the prostate, ... Most prostate tumors begin in the peripheral zone – the outermost part of the prostate. [88]
Peripheral zone (PZ) 70% ... Prostate cancer is one of the most common cancers affecting older men in the UK, US, Northern Europe and Australia, ...
The cancer is typically located in the peripheral zone usually the posterior portion, explaining the rationale of performing the digital rectal exam. [citation needed] Tumors with Gleason scores 8-10 tend to be advanced neoplasms that are unlikely to be cured.
[47]: 694 In BPH, the majority of growth occurs in the transition zone (TZ) of the prostate. [47]: 694 In addition to these two classic areas, the peripheral zone (PZ) is also involved to a lesser extent. [47]: 695 Prostatic cancer typically occurs in the PZ. However, BPH nodules, usually from the TZ are often biopsied anyway to rule out cancer ...
In perineural invasion, cancer cells proliferate around peripheral nerves and eventually invade them. Cancer cells migrate in response to different mediators released by autonomic and sensory fibers. Tumor cells secrete CCL2 and CSF-1 to accumulate endoneurial macrophages and, at the same time, release factors that stimulate perineural invasion.
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