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2. Instrumental chemistry - Wikipedia

   en.wikipedia.org/wiki/Instrumental_chemistry

   Block diagram of an analytical instrument showing the stimulus and measurement of response. ... (HPLC/ESI-MS) Chromatography-diode-array detection (LC-DAD)

3. High-performance liquid chromatography - Wikipedia

   en.wikipedia.org/wiki/High-performance_liquid...

   HPLC has many applications in both laboratory and clinical science. It is a common technique used in pharmaceutical development, as it is a dependable way to obtain and ensure product purity. [59] While HPLC can produce extremely high quality (pure) products, it is not always the primary method used in the production of bulk drug materials. [60]

4. Monolithic HPLC column - Wikipedia

   en.wikipedia.org/wiki/Monolithic_HPLC_column

   A monolithic HPLC column, or monolithic column, is a column used in high-performance liquid chromatography (HPLC). The internal structure of the monolithic column is created in such a way that many channels form inside the column. The material inside the column which separates the channels can be porous and functionalized.

5. Liquid chromatography–mass spectrometry - Wikipedia

   en.wikipedia.org/wiki/Liquid_chromatography...

   The interface between a liquid phase technique (HPLC) with a continuously flowing eluate, and a gas phase technique carried out in a vacuum was difficult for a long time. The advent of electrospray ionization changed this. Currently, the most common LC–MS interfaces are electrospray ionization (ESI), atmospheric pressure chemical ionization ...

6. Reversed-phase chromatography - Wikipedia

   en.wikipedia.org/wiki/Reversed-phase_chromatography

   Silica gel particles are commonly used as a stationary phase in high-performance liquid chromatography (HPLC) for several reasons, [13] [14] including: High surface area: Silica gel particles have a high surface area, allowing direct interactions with solutes or after bonding of variety of ligands for versatile interactions with the sample molecules, leading to better separations.

7. Elution - Wikipedia

   en.wikipedia.org/wiki/Elution

   Elution principle of column chromatography. In analytical and organic chemistry, elution is the process of extracting one material from another by washing with a solvent: washing of loaded ion-exchange resins to remove captured ions, or eluting proteins or other biopolymers from a gel electrophoresis or chromatography column.

8. File:HPLC(high performance liquid chromatography).jpg

   en.wikipedia.org/wiki/File:HPLC(high_performance...

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9. Atmospheric-pressure chemical ionization - Wikipedia

   en.wikipedia.org/wiki/Atmospheric-pressure...

   Atmospheric pressure chemical ionization chamber cross section. Atmospheric pressure chemical ionization (APCI) is an ionization method used in mass spectrometry which utilizes gas-phase ion-molecule reactions at atmospheric pressure (10 5 Pa), [1] [2] commonly coupled with high-performance liquid chromatography (HPLC). [3]