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PCP is self-administered and induces ΔFosB expression in the D1-type medium spiny neurons of the nucleus accumbens, [3] [26] and accordingly, excessive PCP use is known to cause addiction. [3] PCP's rewarding and reinforcing effects are at least partly mediated by blocking the NMDA receptors in the glutamatergic inputs to D1-type medium spiny ...
Pentachlorophenol (PCP) is an organochlorine compound used as a pesticide and a disinfectant.First produced in the 1930s, it is marketed under many trade names. [5] It can be found as pure PCP, or as the sodium salt of PCP, the latter of which dissolves easily in water.
4-Methoxyphencyclidine (methoxydine, 4-MeO-PCP) is a dissociative anesthetic drug that has been sold online as a research chemical. The synthesis of 4-MeO-PCP was first reported in 1965 by the Parke-Davis medicinal chemist Victor Maddox. [ 1 ]
Olney's lesions, also known as NMDA receptor antagonist neurotoxicity (NAT), is a form of brain damage consisting of selective death of neurons but not glia, observed in restricted brain regions of rats and certain other animal models exposed to large quantities of psychoactive drugs that inhibit the normal operation of the neuronal NMDA receptor.
4-Methyl-PCP, 4'-Methyl-PCP and 4''-Methyl-PCP (left to right) However, since the widespread sale of these compounds as grey-market designer drugs, nearly all such compounds that have come to prominence either have a bare cyclohexyl ring or a 2-ketocyclohexyl ring, while the piperidine is replaced by a variety of alkyl or cycloalkyl amines and ...
Dieticyclidine (PCDE), or diethylphenylcyclohexylamine, is a psychoactive drug and research chemical of the arylcyclohexylamine chemical class related to phencyclidine (PCP) and eticyclidine (PCE). It acts as an NMDA receptor antagonist but has low potency and acts mainly as a prodrug for eticyclidine. [1] [2]
LeBron James #23 of the Los Angeles Lakers dribbles the ball during the game against the Utah Jazz on December 1, 2024 at Delta Center in Salt Lake City, Utah.
[5] 3-MeO-PCP has been available for purchase online as a research chemical. [7] It has been found in drug samples in the United Kingdom and Italy. It is also known to be used in France, The Netherlands, Sweden, The United States, Spain, and the Czech Republic. [8] 3-MeO-PCP is usually taken orally or nasally, but can also be injected or smoked ...