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Bergamottin and dihydroxybergamottin are linear furanocoumarins functionalized with side chains derived from geraniol. They are inhibitors of some isoforms of the cytochrome P450 enzyme, in particular CYP3A4. [2] This prevents oxidative metabolism of certain drugs by the enzyme, resulting in an elevated concentration of drug in the bloodstream.
Citrus bergamia, the bergamot orange (pronounced / ˈ b ɜːr ɡ ə m ɒ t /), is a fragrant citrus fruit the size of an orange, with a yellow or green colour similar to a lime, depending on ripeness.
Additive effect [3] Garlic: Allium sativum: Warfarin Additive effect Ginger: Zingiber officinale: Warfarin Additive effect, causes iris bleeding [3] Ginkgo gingko Ginkgo biloba: Aspirin, warfarin, ticlopidine, clopidogrel, dipyridamole, garlic, vitamin E [15] With aspirin – retards aspirin absorption [3] Ginseng: Panax ginseng: Warfarin [15 ...
Bergamot is one of the classic citrus ingredients. The bergamot fruit is small and green, and it smells a bit like lemon. If you’ve ever had Earl Gray tea, you know the scent: it’s somehow ...
Bergapten and other linear furanocoumarins induce a loss of template activity for RNA synthesis. 5-methoxypsoralen has also been noted for its mutagenic effects as well as its capacity for being a very potent agent for inducing chromosome aberrations. With a high enough concentration, complete mitotic inhibition was observed. [4]
Kratom is an herbal supplement made from the leaves of the Mitragyna speciosa tree, which is native to Southeast Asia. Typically, it’s sold and packaged as dried leaves, powders, capsules ...
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