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[42] [43] S. pseudintermedius infections in a human host have been known to cause endocarditis, post-surgical infections, inflammation of the nasal cavity (rhinosinusitis) and catheter-related bacteremia. [6] Staphyloccus pseudintermedius becomes established in a human wound, it has the ability to form antibiotic resistance biofilms. [6]
However, staph infections are still prominent and a cause for concern among healthcare professionals, especially new antibiotic-resistant strains. In the U.S., the incidence of staph infection is around 38.2 to 45.7 per 100,000 person-years, whereas other First World countries have an average incidence rate of 10 to 30 per 100,000 person-years.
Current therapy for S. aureus biofilm-mediated infections involves surgical removal of the infected device followed by antibiotic treatment. Conventional antibiotic treatment alone is not effective in eradicating such infections. [47] An alternative to postsurgical antibiotic treatment is using antibiotic-loaded, dissolvable calcium sulfate ...
Penicillin resistance in Staphylococcus aureus [3] appeared very soon after penicillin entered general clinical use in 1943, and the mechanism of resistance was the production of β-lactamase. Modification of the penicillin molecule so that it was resistant to being broken down by β-lactamase was able to temporarily overcome this problem.
Infections can be localized or systemic, and are often associated with the insertion of medical devices. [6] [7] [8] The highly antibiotic-resistant phenotype and ability to form biofilms make S. haemolyticus a difficult pathogen to treat. [5] Its most closely related species is Staphylococcus borealis. [9]
An antibiotic already in use in Europe to treat pneumonia controlled deadly bloodstream infections with Staphylococcus aureus bacteria just as effectively as the most powerful antibiotic currently ...