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Retinol-binding proteins (RBP) are a family of proteins with diverse functions. They are carrier proteins that bind retinol . Assessment of retinol-binding protein is used to determine visceral protein mass in health-related nutritional studies.
19659 Ensembl ENSG00000114115 ENSMUSG00000046402 UniProt P09455 Q00915 RefSeq (mRNA) NM_002899 NM_001130992 NM_001130993 NM_001365940 NM_011254 RefSeq (protein) NP_001124464 NP_001124465 NP_002890 NP_001352869 NP_035384 Location (UCSC) Chr 3: 139.52 – 139.54 Mb Chr 9: 98.31 – 98.33 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinol binding protein 1, cellular, also known as ...
Retinol-binding protein 4 has been a drug target for eye diseases as RBP4 is the sole carrier for retinol, which is an essential nutrient for the visual cycle. Animal studies using RBP4-antagonists showed that lowering RBP4 can lead to reduction in the accumulation of lipofuscin that leads to vision loss in eye diseases like Stargardt's disease ...
19660 Ensembl ENSG00000114113 ENSMUSG00000032454 UniProt P50120 Q08652 RefSeq (mRNA) NM_004164 NM_009034 RefSeq (protein) NP_004155 NP_033060 Location (UCSC) Chr 3: 139.45 – 139.48 Mb Chr 9: 98.37 – 98.39 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinol-binding protein 2 (RBP2) is a protein that in humans is encoded by the RBP2 gene. Function RBP2 is an abundant protein ...
5949 19661 Ensembl ENSG00000265203 ENSMUSG00000041534 UniProt P10745 P49194 RefSeq (mRNA) NM_002900 NM_015745 RefSeq (protein) NP_002891 NP_056560 Location (UCSC) Chr 10: 47.35 – 47.36 Mb Chr 14: 33.68 – 33.69 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinol-binding protein 3, interstitial (RBP3), also known as interphotoreceptor retinoid-binding protein (IRBP), is a ...
63954 Ensembl ENSG00000162444 ENSMUSG00000028996 UniProt Q96R05 Q9EPC5 RefSeq (mRNA) NM_052960 NM_022020 RefSeq (protein) NP_443192 NP_071303 Location (UCSC) Chr 1: 10 – 10.02 Mb Chr 4: 149.53 – 149.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Retinol binding protein 7 is a protein that in humans is encoded by the RBP7 gene. Function The protein encoded by this gene is a ...
Human retinol-binding protein bound to retinol (vitamin A) in blue. ( PDB : 1RBP ) In protein structures, a beta barrel (β barrel) is a beta sheet (β sheet) composed of tandem repeats that twists and coils to form a closed toroidal structure in which the first strand is bonded to the last strand ( hydrogen bond ).
Unlike retinol, β-carotene is taken up by enterocytes by the membrane transporter protein scavenger receptor B1 (SCARB1). The protein is upregulated in times of vitamin A deficiency. If vitamin A status is in the normal range, SCARB1 is downregulated, reducing absorption. [6]