Ads
related to: aphidicolin cell cycle arrest protocol chart- Free Flow Panel Design
Design panels with our scientists.
Free service, personalized support.
- Flow Cytometry Antibodies
Over 25,000 Abs for flow cytometry.
Over 80 fluorophore options.
- Intracellular Reagents
Get the antibodies, buffers and
compensation beads you need.
- Brilliant Polymer Dyes
BV & BUV Dyes—For violet & UV.
Vast antibody menu.
- NovaFluor—Less Spillover
Low compensation, fill more markers
Dyes for enhanced data resolution
- UltraComp and OneComp
Antibody compensation simplified
One vial, one drop compensation
- Free Flow Panel Design
apexbt.com has been visited by 10K+ users in the past month
Search results
Results From The WOW.Com Content Network
In some experiments, a researcher may want to control and synchronize the time when a group of cells progress to the next phase of the cell cycle. [5] The cells can be induced to arrest as they arrive (at different time points) at a certain phase, so that when the arrest is lifted (for instance, rescuing cell cycle progression by introducing another chemical) all the cells resume cell cycle ...
Steps of the cell cycle. The G 2-M checkpoint occurs between the G 2 and M phases. G2-M arrest. The G 2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms that ensures that cells don't initiate mitosis until damaged or incompletely replicated DNA is sufficiently repaired.
Aphidicolin is a reversible inhibitor of eukaryotic nuclear DNA replication. It blocks the cell cycle at early S phase . It is a specific inhibitor of DNA polymerase Alpha and Delta in eukaryotic cells and in some viruses ( vaccinia [ 1 ] [ 2 ] and herpesviruses ) and an apoptosis inducer in HeLa cells.
The cell cycle checkpoints play an important role in the control system by sensing defects that occur during essential processes such as DNA replication or chromosome segregation, and inducing a cell cycle arrest in response until the defects are repaired. [8]
Steps of the cell cycle. The restriction point occurs between the G 1 and S phases of interphase.. The restriction point (R), also known as the Start or G 1 /S checkpoint, is a cell cycle checkpoint in the G 1 phase of the animal cell cycle at which the cell becomes "committed" to the cell cycle, and after which extracellular signals are no longer required to stimulate proliferation. [1]
APC activity also causes the destruction of S and M cyclins and thus the inactivation of Cdks, which promotes the completion of mitosis and cytokinesis. APC activity is maintained in G1 until G1/S–Cdk activity rises again and commits the cell to the next cycle. This scheme serves only as a general guide and does not apply to all cell types. [1]
In this switch in mammalian cells, there are two cell cycle kinases that help to control the checkpoint: cell cycle kinases CDK4/6-cyclin D and CDK2-cyclin E. [1] The transcription complex that includes Rb and E2F is important in controlling this checkpoint. In the first gap phase, the Rb-HDAC repressor complex binds to the E2F-DP1 ...
"7+3" in the context of chemotherapy is an acronym for a chemotherapy regimen that is most often used today (as of 2014) as first-line induction therapy (to induce remission) in acute myelogenous leukemia, [1] [2] excluding the acute promyelocytic leukemia form, which is better treated with ATRA and/or arsenic trioxide and requires less chemotherapy (if requires it at all, which is not always ...