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An increased level of NEMO gene expression was found in the blood of pregnant women with preeclampsia and their children. [9] However, a decrease of the mRNA levels of total NEMO and the transcripts 1A, 1B, and 1C in placentas derived from preeclamptic women may be the main reason for intensified apoptosis. [ 9 ]
Activator binds to an inducer and the complex binds to the activation sequence and activates target gene. [2] Removing the inducer stops transcription. [2] Because a small inducer molecule is required, the increased expression of the target gene is called induction. [2] The lactose operon is one example of an inducible system. [2]
Regulation of gene expression, or gene regulation, [1] includes a wide range of mechanisms that are used by cells to increase or decrease the production of specific gene products (protein or RNA). Sophisticated programs of gene expression are widely observed in biology, for example to trigger developmental pathways, respond to environmental ...
10912 23882 Ensembl ENSG00000130222 ENSMUSG00000021453 UniProt O95257 Q9Z111 Q9R0S0 RefSeq (mRNA) NM_006705 NM_011817 RefSeq (protein) NP_006696 NP_035947 Location (UCSC) Chr 9: 89.61 – 89.61 Mb Chr 13: 52 – 52 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Growth arrest and DNA-damage-inducible protein GADD45 gamma is a protein that in humans is encoded by the GADD45G gene on ...
1027 12576 Ensembl ENSG00000111276 ENSMUSG00000003031 UniProt P46527 P46414 RefSeq (mRNA) NM_004064 NM_009875 RefSeq (protein) NP_004055 NP_034005 Location (UCSC) Chr 12: 12.69 – 12.72 Mb Chr 6: 134.9 – 134.9 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cyclin-dependent kinase inhibitor 1B (p27 Kip1) is an enzyme inhibitor that in humans is encoded by the CDKN1B gene. It ...
A regulatory sequence is a segment of a nucleic acid molecule which is capable of increasing or decreasing the expression of specific genes within an organism. Regulation of gene expression is an essential feature of all living organisms and viruses.
Activin also regulates the morphogenesis of branching organs such as the prostate, lung, and especially kidney. Activin A increased the expression level of type-I collagen suggesting that activin A acts as a potent activator of fibroblasts. Lack of activin during development results in neural developmental defects.
CREB (top) is a transcription factor capable of binding DNA (bottom) and regulating gene expression. CREB-TF (CREB, cAMP response element-binding protein) [1] is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. [2]