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While the exact cause or causes are unknown, Crohn's disease seems to be due to a combination of environmental factors and genetic predisposition. [96] Crohn's is the first genetically complex disease in which the relationship between genetic risk factors and the immune system is understood in considerable detail. [ 97 ]
Other gastrointestinal disorders like Whipple's disease, celiac disease, and intestinal bypass surgery for severe obesity can also cause joint involvement. The pathogenesis of arthritis in these conditions is likely influenced by immunologic, genetic, and abnormal bowel permeability factors, though the precise mechanisms are still unknown.
In Crohn's disease, surgery involves removing the worst inflamed segments of the intestine and connecting the healthy regions, but unfortunately, it does not cure Crohn's or eliminate the disease. At some point after the first surgery, Crohn's disease can recur in the healthy parts of the intestine, usually at the resection site. [76] (For ...
Crohn’s is an autoimmune disorder that causes inflammation and damage to the gastrointestinal (GI) tract, according to the U.S. Centers for Disease Control and Prevention. Crohn’s disease may ...
Ulcerative colitis or Crohn's disease may cause colonic obstruction. The obstruction may be acute or chronic after years of uncontrolled disease leads to the formation of strictures and fistulas. The medical history is helpful in that most cases of inflammatory bowel disease are well known to both patient and doctor.
This may cause more pain or gastrointestinal upset, says de Latour. ... which can be due to various factors including genetics, exposure to spicy foods and personality. ... (such as Crohn's ...
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