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Orosomucoid (ORM) or alpha-1-acid glycoprotein (α 1 AGp, [1] AGP or AAG) is an acute phase protein found in plasma. It is an alpha-globulin glycoprotein and is modulated by two polymorphic genes. It is synthesized primarily in hepatocytes and has a normal plasma concentration between 0.6–1.2 mg/mL (1–3% plasma protein). [ 2 ]
Phenoxybenzamine has a long-lasting action, binding covalently to the alpha receptors. Its only current clinical use is in preparing patients with pheochromocytoma for surgery; its irreversible antagonism and the resultant depression in the maximum of the agonist dose-response curve are desirable in a situation where surgical manipulation of ...
18407 Ensembl ENSG00000229314 ENSMUSG00000028359 UniProt P02763 Q63805 RefSeq (mRNA) NM_000607 NM_013623 NM_001379520 NM_001379521 RefSeq (protein) NP_000598 n/a Location (UCSC) Chr 9: 114.32 – 114.33 Mb Chr 4: 63.27 – 63.28 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Alpha-1-acid glycoprotein 1 is a protein that in humans is encoded by the ORM1 gene. This gene encodes a key ...
Alpha 1 blocker exerts its action on alpha-1 receptor, dilating the smooth muscles. [3] Alpha-1 receptor is a Gq type G-protein coupled receptor . [ 3 ] When it is activated, it will lead to activation of phospholipase C , raising the intracellular level of IP3 and DAG . [ 3 ]
Alpha-1 blocker, blocks alpha receptors and it relaxes the smooth muscles in the bladder. It helps the urine to flow smoothly and it can lessen the pain caused by the bladder pressing on the prostate. [44] [45] Selective alpha-1 blockers are better tolerated than non-selective alpha blockers in the body and therefore works better on BPH. [2]
Basic drugs will bind to the acidic alpha-1 acid glycoprotein. This is significant because various medical conditions may affect the levels of albumin, alpha-1 acid glycoprotein, and lipoproteins. This is significant because various medical conditions may affect the levels of albumin, alpha-1 acid glycoprotein, and lipoproteins.
Alpha-1 antitrypsin deficiency (A1AD or AATD) is a genetic disorder that may result in lung disease or liver disease. [1] Onset of lung problems is typically between 20 and 50 years of age. [ 1 ] This may result in shortness of breath , wheezing , or an increased risk of lung infections .
Alpha-1-B glycoprotein is a 54.3 kDa protein in humans that is encoded by the A1BG gene. [ 5 ] The protein encoded by this gene is a plasma glycoprotein of unknown function. The protein shows sequence similarity to the variable regions of some immunoglobulin supergene family member proteins.
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