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Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [8] [9] It may also be used for hiccups and muscle spasms near the end of life, [9] and off-label to treat alcohol use disorder [10] [11] or opioid withdrawal symptoms. [12]
In a medicine that is administered periodically, the trough level should be measured just before the administration of the next dose in order to avoid overdosing. [3] A trough level is contrasted with a "peak level" ( C max ), which is the highest level of the medicine in the body, and the "average level", which is the mean level over time.
C min is a term used in pharmacokinetics for the minimum blood plasma concentration reached by a drug during a dosing interval, which is the time interval between administration of two doses. This definition is slightly different from C trough, the concentration immediately prior to administration of the next dose. [1]
[17] [18] It has between 30- and 68-fold lower affinity for the GABA B receptor than baclofen, and, in accordance, is used at far higher doses in comparison. [17] R )-Phenibut has more than 100-fold higher affinity for the GABA B receptor than does ( S )-phenibut; hence, ( R )-phenibut is the active enantiomer at the GABA B receptor.
While it can be used in patients with muscle spasm of almost any origin, it produces sedation in most individuals at the doses required to reduce muscle tone. [ 5 ] Baclofen is considered to be at least as effective as diazepam in reducing spasticity, and causes much less sedation.
The median effective dose is the dose that produces a quantal effect (all or nothing) in 50% of the population that takes it (median referring to the 50% population base). [6] It is also sometimes abbreviated as the ED 50, meaning "effective dose for 50% of the population". The ED50 is commonly used as a measure of the reasonable expectancy of ...
Intrathecal pumps require maintenance and need to be periodically refilled. How frequently this occurs is dependent on several factors, including drug concentration and dosage, and pump size. The refill frequency can range between one and six months for baclofen pumps. [2]
Baclofen DOES produce euphoria and "high" in dosage of about 125mg, a halfway between alcohol and "Extasy" (MDMA) experience. Just buy it and try it if you need a proof. — Preceding unsigned comment added by 94.102.122.86 ( talk ) 18:45, 7 March 2017 (UTC) [ reply ]