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Topical fluorides are fluoride-containing drugs indicated in prevention and treatment of dental caries, particularly in children's primary dentitions. [1] The dental-protecting property of topical fluoride can be attributed to multiple mechanisms of action, including the promotion of remineralization of decalcified enamel, the inhibition of the cariogenic microbial metabolism in dental plaque ...
Sodium fluoride (NaF) is an inorganic compound with the formula Na F.It is a colorless or white solid that is readily soluble in water. It is used in trace amounts in the fluoridation of drinking water to prevent tooth decay, and in toothpastes and topical pharmaceuticals for the same purpose.
Castor oil and its derivatives are found in many cosmetics as it is "non-comedogenic" (does not exacerbate or contribute to acne). [3]Cerebrosides (cells from the nervous systems of cattle or swine) were once used in some high-end skin-care products to increase moisture retention and to create a smooth skin surface, [4] however the BSE controversy has put an end to this practice.
Soluble fluoride salts, of which sodium fluoride is the most common, are toxic, and have resulted in both accidental and self-inflicted deaths from acute poisoning. [4] The lethal dose for most adult humans is estimated at 5 to 10 g (which is equivalent to 32 to 64 mg elemental fluoride per kg body weight).
Skin absorption relates to the degree of exposure to and possible effect of a substance which may enter the body through the skin. Human skin comes into contact with many agents intentionally and unintentionally. Skin absorption can occur from occupational, environmental, or consumer skin exposure to chemicals, cosmetics, or pharmaceutical ...
Fluoride's suppressive effect on the thyroid is more severe when iodine is deficient, and fluoride is associated with lower levels of iodine. [clarification needed] [32] Thyroid effects in humans were associated with fluoride levels 0.05–0.13 mg/kg/day when iodine intake was adequate and 0.01–0.03 mg/kg/day when iodine intake was inadequate.
The dose that may lead to adverse health effects is about one fifth of the lethal dose. [69] Chronic excess fluoride consumption can lead to skeletal fluorosis, a disease of the bones that affects millions in Asia and Africa. [69] [70] The fluoride ion is readily absorbed by the stomach and intestines.
Cleansing is a standard step in skin care routines. Skin cleansing includes some or all of these steps or cosmetics: Cleansers or foaming washes are used to remove excess dirt, oil, and makeup left on the skin. [24] Different cleansing products are aimed at various types of skin, such as sulfate-free cleansers and spin brushes. [24]