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Eosinophilic bronchitis. Eosinophilic bronchitis (EB) is a type of airway inflammation due to excessive mast cell recruitment and activation in the superficial airways as opposed to the smooth muscles of the airways as seen in asthma. [1][2] It often results in a chronic cough. [1] Lung function tests are usually normal. [1]
Many diseases, such as asthma and eczema, are caused when eosinophils overreact to environmental triggers and release an excess of chemicals, e.g., cytokines and histamine. The common characteristic among different causes of eosinophilic pneumonia is eosinophil overreaction or dysfunction in the lungs.
Asthma is a long-term inflammatory disease of the airways of the lungs. [ 4 ] It is characterized by variable and recurring symptoms, reversible airflow obstruction, and easily triggered bronchospasms. [ 9 ][ 10 ] Symptoms include episodes of wheezing, coughing, chest tightness, and shortness of breath. [ 3 ]
Eosinophils, sometimes called eosinophiles or, less commonly, acidophils, are a variety of white blood cells and one of the immune system components responsible for combating multicellular parasites and certain infections in vertebrates. [2] Along with mast cells and basophils, they also control mechanisms associated with allergy and asthma.
Asthma trigger. Asthma triggers are factors or stimuli that provoke the exacerbation of asthma symptoms or increase the degree of airflow disruption, which can lead to an asthma attack. [1] An asthma attack is characterized by an obstruction of the airway, hypersecretion of mucus and bronchoconstriction due to the contraction of smooth muscles ...
Nucala is a monoclonal antibody that inhibits interleukin-5, which helps regulate eosinophils, a type of white blood cell that causes inflammation in th GSK's asthma drug Nucala meets main goal in ...
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