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Biological half-life (elimination half-life, pharmacological half-life) is the time taken for concentration of a biological substance (such as a medication) to decrease from its maximum concentration (C max) to half of C max in the blood plasma. [1][2][3][4][5] It is denoted by the abbreviation . [2][4] This is used to measure the removal of ...
Drug expiration. Drug expiration is the date after which a drug might not be suitable for use as manufactured. Consumers can determine the shelf life for a drug by checking its pharmaceutical packaging for an expiration date. Drugs which are past their shelf life can decompose [1] and either be ineffective [2] or even harmful. [2]
Plateau principle. The plateau principle is a mathematical model or scientific law originally developed to explain the time course of drug action (pharmacokinetics). [1] The principle has wide applicability in pharmacology, physiology, nutrition, biochemistry, and system dynamics. It applies whenever a drug or nutrient is infused or ingested at ...
Shelf life. This pack of diced pork says 'Display until' 7 May and 'Use by' 8 May. Shelf life is the length of time that a commodity may be stored without becoming unfit for use, consumption, or sale. [1] In other words, it might refer to whether a commodity should no longer be on a pantry shelf (unfit for use), or no longer on a supermarket ...
In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [1] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life.
Elimination (pharmacology) In pharmacology, the elimination or excretion of a drug is understood to be any one of a number of processes by which a drug is eliminated (that is, cleared and excreted) from an organism either in an unaltered form (unbound molecules) or modified as a metabolite. The kidney is the main excretory organ although others ...
Elimination rate constant. The elimination rate constant K or Ke is a value used in pharmacokinetics to describe the rate at which a drug is removed from the human system. [1] It is often abbreviated K or Ke. It is equivalent to the fraction of a substance that is removed per unit time measured at any particular instant and has units of T −1.
Volume of distribution. In pharmacology, the volume of distribution (V D, also known as apparent volume of distribution, literally, volume of dilution[1]) is the theoretical volume that would be necessary to contain the total amount of an administered drug at the same concentration that it is observed in the blood plasma. [2]