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A review of 136 patients in seven studies who were given more than 500 mg for a month showed 25 cases of diarrhea, 8 cases of abdominal pain, 7 cases of nausea, and 5 cases of flatulence. [52] A 2018 review of resveratrol effects on blood pressure found that some people had increased frequency of bowel movements and loose stools. [16]
Pterostilbene is considered to be a corrosive substance, is dangerous upon exposure to the eyes, and is an environmental toxin, especially to aquatic life. [1] A preliminary study of healthy human subjects given pterostilbene for 6–8 weeks, showed pterostilbene to be safe for human use at dosages up to 250 mg per day, although this study did not assess metabolic effects on the lipid profile.
Dihydro-resveratrol is a dihydrostilbenoid found in wine. [1] [2] It is also a metabolite of trans-resveratrol formed in the intestine by the hydrogenation of the double bond by microflora. [3] It is also a non-cannabinoid estrogenic compound found in cannabis. [4] [full citation needed]
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Resveratrol can be produced from piceid by the mold Aspergillus oryzae, [3] the mold used to make sake and soy sauce, as the fungus produces a potent beta-glucosidase. [ 4 ] trans -Piceid is the glucoside formed with trans -resveratrol, while cis -piceid is formed with cis -resveratrol.
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