Search results
Results From The WOW.Com Content Network
A data pack (or fact pack) is a pre-made database that can be fed to a software, such as software agents, game, Internet bots or chatterbots, to teach information and facts, which it can later look up. [1] In other words, a data pack can be used to feed minor updates into a system. [2]
[2] [3] It is a selective α 1-adrenergic blocker in the quinazoline class of compounds. [2] Doxazosin was patented in 1977 and came into medical use in 1988. [4] It is available as a generic medication. [3] In 2022, it was the 180th most commonly prescribed medication in the United States, with more than 2 million prescriptions. [5] [6]
[16] [17] [18] It is a 5–10× more potent beta blocker than propranolol. Timolol is light-sensitive; it is usually preserved with 0.01% benzalkonium chloride (BAC), but also comes BAC-free. It can also be used in combination with pilocarpine , carbonic anhydrase inhibitors [ 19 ] or prostaglandin analogs.
The T max of doxylamine is 1.5 to 2.5 hours. [2] Its elimination half-life is 10 to 12 hours (range 7 to 15 hours). [2] [3] [4] Doxylamine is metabolized in the liver primarily by the cytochrome P450 enzymes CYP2D6, CYP1A2, and CYP2C9. [2] [40] The main metabolites are N-desmethyldoxylamine, N,N-didesmethyldoxylamine, and doxylamine N-oxide. [41]
It is a beta blocker, specifically a selective β 1 receptor blocker, and is taken by mouth or is given intravenously. [4] Common side effects include trouble sleeping, feeling tired, feeling faint, and abdominal discomfort. [4] Large doses may cause serious toxicity. [5] [6] Risk in pregnancy has not been ruled out.
[2] [22] In particular, it is a partial agonist at β 2-adrenergic receptors located in the vascular smooth muscle. Labetalol relaxes vascular smooth muscle by a combination of this partial β 2-adrenergic receptor agonism and through α 1-adrenergic receptor blockade. [22] [25] Overall, this vasodilatory effect can decrease blood pressure. [26]
Tezacaftor is a medication used for the treatment of cystic fibrosis. [1] [2] It is available in fixed-dose combination medications.[3] [4] [5]The combination of tezacaftor with ivacaftor (brand name Symdeko) was approved for medical use in the United States in February 2018, [6] [1] and in Canada in June 2018. [7]
Woody, spiny, evergreen, heteroblastic plant 2–10 m in height with one to several trunks 3–40 cm in diameter, trunks spreading upward and outward from base; bark thin, grey-green, streaked with corky, longitudinal fissures, becoming reticulate and somewhat rough, reddish to greyish brown / buff; branches smooth, grey-green and armed with spines; branchlets cylindrical, those of current ...