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[6] [5] Fluconazole is in the azole antifungal family of medication. [5] It is believed to work by affecting the fungal cellular membrane. [5] Fluconazole was patented in 1981 and came into commercial use in 1988. [7] It is on the World Health Organization's List of Essential Medicines. [8] Fluconazole is available as a generic medication. [5]
Tofacitinib claims to have no contraindications, but doctors are advised to reduce the patient's dosage when combined with "potent inhibitors of cytochrome P450 3A4 (CYP3A4)," such as ketoconazole, or one or more combined medications that result in both moderate inhibition of CYP3A4 and potent inhibition of CYP2C19 such as fluconazole.
In 2006, Sanofi-Aventis SA and Bristol-Myers Squibb Co., the producers and patent owners of Plavix, the blood thinner drug, settled a patent lawsuit with Apotex. [23] [24] In the settlement, Apotex agreed not to sell a generic version of Plavix until September 2011, in exchange for an unspecified amount of money. [23]
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