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Lymph node metastasis is the spread of cancer cells into a lymph node.. Lymph node metastasis is different from malignant lymphoma.Lymphoma is a cancer of lymph node, rather than cancer in the lymph node, because lymphoma originates from the lymph node itself, instead of originating elsewhere (e.g., the breast or colon) and spreading to the lymph nodes.
N1: regional lymph node metastasis present; at some sites, tumor spread to closest or small number of regional lymph nodes; N2: tumor spread to an extent between N1 and N3 (N2 is not used at all sites) N3: tumor spread to more distant or numerous regional lymph nodes (N3 is not used at all sites) M: presence of distant metastasis. M0: no ...
Cut surface of a liver showing multiple paler metastatic nodules originating from pancreatic cancer. Initially, nearby lymph nodes are struck early. [10] The lungs, liver, brain, and bones are the most common metastasis locations from solid tumors. [10] In lymph node metastasis, a common symptom is lymphadenopathy
Lymphovascular invasion, especially in carcinomas, usually precedes spread to the lymph nodes that drain the tissue in which the tumour arose. Conversely, cancers with lymph node spread (known as a lymph node metastases), usually have lymphovascular invasion. Lymph node metastases usually precede secondary tumours, i.e. distant metastases.
The detection of micrometastases in the sentinel lymph nodes (SLN) is the primary indicator of its spread to the regional lymph nodes, bone marrow, peripheral blood and ultimately to distant metastatic sites, since they are the first of the nodes that cancer would travel to. [3]
The concept of the sentinel lymph node is important because of the advent of the sentinel lymph node biopsy technique, also known as a sentinel node procedure.This technique is used in the staging of certain types of cancer to see if they have spread to any lymph nodes, since lymph node metastasis is one of the most important prognostic signs.