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Clopidogrel, sold under the brand name Plavix among others, is an antiplatelet medication used to reduce the risk of heart disease and stroke in those at high risk. [10] It is also used together with aspirin in heart attacks and following the placement of a coronary artery stent ( dual antiplatelet therapy ). [ 10 ]
On average 28,726 hospitalized adults aged 18 and older with a VTE blood clot diagnosis die each year. [11] Risk of thrombosis is related to hospitalization. [ 4 ] In 2005 the UK the Parliamentary Health Select Committee determined the annual rate of death due to thrombosis was 25,000 with at least 50% being hospital-acquired.
Often a combination of aspirin plus an ADP/P2Y inhibitor [7] (such as clopidogrel, prasugrel, ticagrelor, or another) is used to obtain greater effectiveness than with either agent alone. This is known as "dual antiplatelet therapy" (or DAPT ).
In a study funded by Novo Nordisk released last April, patients reportedly regained two-thirds of the weight they lost after just one year of stopping the drug treatment. Show comments.
The data, published in the journal JAMA, showed patients who were obese and without diabetes experienced a 14% weight regain nearly a year after they switched to a placebo from an eight-month ...
An anticoagulant, commonly known as a blood thinner, is a chemical substance that prevents or reduces the coagulation of blood, prolonging the clotting time. [1] Some occur naturally in blood-eating animals, such as leeches and mosquitoes, which help keep the bite area unclotted long enough for the animal to obtain blood.
[55] [57] An interaction between PPIs and the metabolism of the platelet inhibitor clopidogrel is known and this drug is also often used in people with cardiac disease. [ 58 ] [ 59 ] [ 22 ] There are associations with an increased risk of stroke, but this appears to be more likely to occur in people who already have an elevated risk.
With plasma exchange the risk of death has decreased from more than 90% to less than 20%. [1] Immunosuppressants, such as glucocorticoids, and rituximab may also be used. [3] Platelet transfusions are generally not recommended. [6] About 1 per 100,000 people are affected. [3] Onset is typically in adulthood and women are more often affected. [3]