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In the early 2000s, a group of researchers led by prof V. P. Skulachev in Moscow State University began the development of SkQ — the mitochondrial-targeted antioxidant, similar to MitoQ, but with the ubiquinone replaced with plastoquinone (more active analog of ubiquinone derived from plant chloroplasts). [9]
Coenzyme Q 10 (CoQ 10 / ˌ k oʊ k j uː ˈ t ɛ n /), also known as ubiquinone, is a naturally occurring biochemical cofactor (coenzyme) and an antioxidant produced by the human body. [ 1 ] [ 2 ] [ 3 ] It can also be obtained from dietary sources, such as meat, fish, seed oils, vegetables, and dietary supplements .
Plastoquinone (PQ) is a terpenoid-quinone (meroterpenoid) molecule involved in the electron transport chain in the light-dependent reactions of photosynthesis. The most common form of plastoquinone, known as PQ-A or PQ-9, is a 2,3-dimethyl-1,4-benzoquinone molecule with a side chain of nine isoprenyl units.
Ubiquinone-10 is a naturally occurring 1,4-benzoquinone involved in respiration apparatus. Plastoquinone is a redox relay involved in photosynthesis. Pyrroloquinoline quinone is another biological redox cofactor. Ubiquinones, as their name implies, are ubiquitous in living creatures, being components of respiratory apparatus.
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