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It was discovered in 2000 as one of two improved mutants by H. Bujard and his colleagues after random mutagenesis of the Tet repressor part of the transactivator gene. [6] Tet-On 3G (also known as rtTA-V10 [7]) is similar to Tet-On Advanced but was derived from rtTA2 S-S2 rather than rtTA2 S-M2. It is also human codon optimized and composed of ...
Clues to the existence of a post-mortem transcriptome existed at least since the beginning of the 21st century, [4] but the word thanatotranscriptome (from (thanatos-, Greek for "death") seems to have been first used in the scientific literature by Javan et al. in 2015, [2] following the introduction of the concept of the human thanatomicrobiome in 2014 at the 66th Annual Meeting of the ...
One particular TET enzyme, TET1, and TDG are present at high levels from embryo day 9.5 to 13.5, [22] and are employed in active TET-dependent demethylation during gametogenesis. [21] PGC genomes display the lowest levels of DNA methylation of any cells in the entire life cycle of the mouse by embryonic day 13.5.
21752 Ensembl ENSG00000164362 ENSMUSG00000021611 UniProt O14746 O70372 RefSeq (mRNA) NM_001193376 NM_198253 NM_198254 NM_198255 NM_009354 NM_001362387 NM_001362388 RefSeq (protein) NP_001180305 NP_937983 NP_033380 NP_001349316 NP_001349317 Location (UCSC) Chr 5: 1.25 – 1.3 Mb Chr 13: 73.78 – 73.8 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Telomerase reverse transcriptase ...
For example, cocaine can be detected in the blood for two to ten days, while it can be detected in urine for two to five days. The results of post-mortem toxicology testing are interpreted alongside the victim's history, a thorough investigation of the scene, and autopsy and ancillary study findings to determine the manner of death. [7]
Tet Repressor proteins (otherwise known as TetR) are proteins playing an important role in conferring antibiotic resistance to large categories of bacterial species. Tetracycline (Tc) is a broad family of antibiotics to which bacteria have evolved resistance. Tc normally kills bacteria by binding to the bacterial ribosome and halting protein ...
Ten-eleven translocation methylcytosine dioxygenase 1 (TET1) is a member of the TET family of enzymes, in humans it is encoded by the TET1 gene.Its function, regulation, and utilizable pathways remain a matter of current research while it seems to be involved in DNA demethylation and therefore gene regulation, [5] [6] but is expressed as different isoforms which may have distinct functions.
194388 Ensembl ENSG00000187605 ENSMUSG00000034832 UniProt O43151 Q8BG87 RefSeq (mRNA) NM_001287491 NM_001366022 NM_183138 NM_001347313 RefSeq (protein) NP_001274420 NP_001352951 NP_001334242 NP_898961 Location (UCSC) Chr 2: 73.98 – 74.11 Mb Chr 6: 83.34 – 83.44 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Tet methylcytosine dioxygenase 3 is a protein that in humans is encoded ...