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Diffusing capacity of the lung (D L) (also known as transfer factor) measures the transfer of gas from air in the lung, to the red blood cells in lung blood vessels. It is part of a comprehensive series of pulmonary function tests to determine the overall ability of the lung to transport gas into and out of the blood.
D LCO or T LCO (diffusing capacity or transfer factor of the lung for carbon monoxide (CO), [1]) is the extent to which oxygen passes from the air sacs of the lungs into the blood. Commonly, it refers to the test used to determine this parameter. It was introduced in 1909. [2]
A nitrogen washout can obtain the following parameters: Closing volume (CV); the amount of air remaining in the lungs beyond that of the residual volume when the flow from the lower sections of the lungs becomes severely reduced or halts altogether during expiration as the small airways begin to close.
Figure A shows the location of the lungs and airways in the body. The inset image shows a detailed view of the lung's airways and air sacs in cross-section. Figure B shows fibrosis (scarring) in the lungs. The inset image shows a detailed view of the fibrosis and how it damages the airways and air sacs. [1] Specialty: Pulmonology: Symptoms
Pulmonary function measurements are reduced, as indicated by a reduction in the amount of air that the lungs can hold (vital capacity) and changes in expiratory function and lung elasticity. [31] [32] Lung diffusing capacity decreases leading eventually to hypoxaemia. [27]
Impaired diffusion, a reduced capacity for gas molecules to move between the air in the alveoli and the blood, which occurs when alveolar–capillary membranes thicken. This can happen in interstitial lung diseases such as pulmonary fibrosis, sarcoidosis, hypersensitivity pneumonitis, and connective tissue disorders. [7]
Air in the alveoli of the lungs is diluted by saturated water vapour (H 2 O) and carbon dioxide (CO 2), a metabolic product given off by the blood, and contains less oxygen (O 2) than atmospheric air as some of it is taken up by the blood for metabolic use. The resulting partial pressure of nitrogen is about 0.758 bar.
Decreased concentration of oxygen in inspired air caused by reduced replacement of oxygen in the breathing mix. Anaesthetics. Low partial pressure of oxygen in the lungs when switching from inhaled anesthesia to atmospheric air, due to the Fink effect, or diffusion hypoxia. Air depleted of oxygen has also proven fatal.