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  2. Recreational use of dextromethorphan - Wikipedia

    en.wikipedia.org/wiki/Recreational_use_of...

    William E. White, author of the "DXM FAQ", has compiled informal research from correspondence with dextromethorphan users suggesting that heavy abuse may result in various deficits corresponding to the brain areas affected by Olney's lesions; these include loss of episodic memory, decline in ability to learn, abnormalities in some aspects of ...

  3. Dextromethorphan regulation by U.S. jurisdiction - Wikipedia

    en.wikipedia.org/wiki/Dextromethorphan...

    Dextromethorphan is a cough suppressant found in several cold medications. ... legislation to combat teen abuse of over-the-counter (OTC) medicines containing the ...

  4. Lean (drug) - Wikipedia

    en.wikipedia.org/wiki/Lean_(drug)

    Dextromethorphan syrup Lean or purple drank (known by numerous local and street names ) is a polysubstance drink used as a recreational drug . It is prepared by mixing prescription-grade cough or cold syrup containing an opioid drug and an anti-histamine drug with a soft drink and sometimes hard candy .

  5. Dextromethorphan - Wikipedia

    en.wikipedia.org/wiki/Dextromethorphan

    Dextromethorphan, sold under the brand name Robitussin among others, is a cough suppressant used in many cough and cold medicines. [6] In 2022, the US Food and Drug Administration (FDA) approved the combination dextromethorphan/bupropion to serve as a rapid-acting antidepressant in people with major depressive disorder.

  6. Olney's lesions - Wikipedia

    en.wikipedia.org/wiki/Olney's_lesions

    Olney's lesions, also known as NMDA receptor antagonist neurotoxicity (NAT), is a form of brain damage consisting of selective death of neurons but not glia, observed in restricted brain regions of rats and certain other animal models exposed to large quantities of psychoactive drugs that inhibit the normal operation of the neuronal NMDA receptor.

  7. Breakthrough antidepressants with fewer side effects could ...

    www.aol.com/finance/breakthrough-antidepressants...

    Ketamine’s antidepressant effects are part of what prompted researchers to explore other drugs that target glutamate—like the venerable cough suppressant dextromethorphan found in Robitussin ...

  8. New treatments are needed for alcohol addiction. Are drugs ...

    www.aol.com/treatments-needed-alcohol-addiction...

    Dr. Lorenzo Leggio, a scientist at the National Institute on Drug Abuse in Baltimore, works closely with Simmons. He’s the lead investigator of a similar trial in Baltimore, called STAR-B.

  9. List of polysubstance combinations - Wikipedia

    en.wikipedia.org/wiki/List_of_polysubstance...

    DXM: Psilocybin or psilocybin mushroom: Cherry-bomb Cherry-bombing Fentanyl: Heroin: Birria, chiva loca, Facebook Facebook is mixed in a pill form [citation needed] Fentanyl (and/or heroin) Xylazine: Tranq, Tranq dope "Tranq" is sometimes used to refer to xylazine by itself, but as a drug of abuse it is invariably combined with heroin or ...