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Intrinsic factor is required for the absorption of vitamin B 12 in the diet. A long-term deficiency in vitamin B 12 can lead to megaloblastic anemia, characterized by large fragile red blood cells. Pernicious anaemia results from autoimmune destruction of gastric parietal cells, precluding the synthesis of intrinsic factor and, by extension ...
Intrinsic factor (IF), cobalamin binding intrinsic factor, [5] also known as gastric intrinsic factor (GIF), is a glycoprotein produced by the parietal cells (in humans) or chief cells (in rodents) of the stomach. It is necessary for the absorption of vitamin B 12 later on in the distal ileum of the small intestine. [6]
The same cells in the stomach that produce gastric hydrochloric acid, the parietal cells, also produce a molecule called the intrinsic factor (IF), which binds the B 12 after its release from haptocorrin by digestion, and without which only 1% of vitamin B 12 is absorbed. Intrinsic factor (IF) is a glycoprotein, with a molecular weight of 45 kDa.
An internationalised vector image was then created by User:Silversmith and uploaded to Commons as Image:Schematic diagram of the human eye.svg (see right). On request, this version with English annotations was created and uploaded here. Later, the text labels were made into hyperlinks pointing at relevant articles in the English Wikipedia.
Diagram of a human eye (horizontal section of the right eye) 1. Lens, 2. Zonule of Zinn or Ciliary zonule, 3. Posterior chamber and 4. Anterior chamber with 5. Aqueous humour flow; 6. Pupil, 7. Corneosclera or Fibrous tunic with 8. Cornea, 9. Trabecular meshwork and Schlemm's canal. 10. Corneal limbus and 11. Sclera; 12. Conjunctiva, 13. Uvea ...
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Parietal cells, stomach epithelium cells that secrete gastric acid and intrinsic factor to aid in digestion. The parietal bone . Topics referred to by the same term
Diagram of a human eye; note that not all eyes have the same anatomy as a human eye. The mammalian eye can also be divided into two main segments: the anterior segment and the posterior segment. [10] The human eye is not a plain sphere but is like two spheres combined, a smaller, more sharply curved one and a larger lesser curved sphere.