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They develop in the cerebellar primordium that covers the fourth ventricle and below a fissure-like region called the isthmus of the developing brain. Purkinje cells migrate toward the outer surface of the cerebellar cortex and form the Purkinje cell layer. Purkinje cells are born during the earliest stages of cerebellar neurogenesis.
The cerebellum is the section ... These "zones" of the flocculus refer to five separate groupings of Purkinje cells that project to different areas of the brain ...
This area produces Purkinje cells and deep cerebellar nuclear neurons. These cells are the primary output neurons of the cerebellar cortex and cerebellum. The second germinal zone (cellular birthplace) is known as the rhombic lip, neurons then move by human embryonic week 27 to the external granular layer. This layer of cells—found on the ...
Purkinje cells receive more synaptic inputs than any other type of cell in the brain—estimates of the number of spines on a single human Purkinje cell run as high as 200,000. [11] The large, spherical cell bodies of Purkinje cells are packed into a narrow layer (one cell thick) of the cerebellar cortex, called the Purkinje layer.
Lugaro cells are primary sensory interneurons of the cerebellum, that have an inhibitory function. They are fusiform, having a spindle shape that tapers at each end. They were first described by Ernesto Lugaro in the early 20th century. Lugaro cells are found just beneath the layer of Purkinje cells between the molecular layer and the granular ...
There are four paired deep cerebellar nuclei embedded in the white matter centre of the cerebellum. The nuclei are the fastigial , globose , emboliform , and dentate nuclei. In lower mammals the emboliform nucleus appears to be continuous with the globose nucleus, and these are known together as the interposed nucleus .
The target for each climbing fiber is a specific neuron in the cerebellum referred to as a Purkinje Cell. During development, there are multiple climbing fibers on a purkinje cell, however these are pruned off during postnatal development, thus leaving a mature purkinje cell with a single climbing fiber. There are three major components of the ...
This period is an important developmental stage of the cerebellum. The expansion of the EGL precursor cells creates a large population of neurons that outnumber Purkinje cells 250:1 in the adult cerebellar cortex. [6] The granule neurons in EGL express genes that play a specific and crucial role in cell proliferation.