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In it Burnet expanded the ideas of Talmage and named the resulting theory the "clonal selection theory". He further formalised the theory in his 1959 book The Clonal Selection Theory of Acquired Immunity. He explained immunological memory as the cloning of two types of lymphocyte. One clone acts immediately to combat infection whilst the other ...
Niels Kaj Jerne, FRS [1] (23 December 1911 – 7 October 1994) was a Danish immunologist.He shared the Nobel Prize in Physiology or Medicine in 1984 with Georges J. F. Köhler and César Milstein "for theories concerning the specificity in development and control of the immune system and the discovery of the principle for production of monoclonal antibodies".
The germ-line theory was a proposed explanation for immunoglobulin diversity that proposed that each antibody was encoded in a separate germline gene. [ 1 ] [ 2 ] This does not occur in most species (including humans), but may occur in Elasmobranchs .
The theory accounts for the ability of T cells to have regulatory roles in both helping and suppressing immune responses. In 1976 Murphy et al. and Tada et al. independently reported a phenomenon in mice called I-J. [17] [18] From the perspective of the symmetrical network theory, I-J is one of the most important phenomena in immunology, while for many immunologists who are not familiar with ...
The second book, Topobiology (1988), [21] proposes a theory of how the original neuronal network of a newborn's brain is established during development of the embryo. The Remembered Present (1990) [ 22 ] contains an extended exposition of his theory of consciousness .
The arrangement or processes that put together different parts of this antibody molecule play important role in antibody diversity and production of different subclasses or classes of antibodies. The organization and processes take place during the development and differentiation of B cells. That is, the controlled gene expression during ...
Burnet's work continued and in 1957 along with Niels Jerne published a paper that modified and revolutionized antibody theory. "Burnet speculated that one cell makes one particular shape of antibody and that all our antibody-making immune cells together make an unimaginably vast repertoire of 10 billion antibodies, each having a slightly ...
The side-chain theory (German, Seitenkettentheorie) is a theory proposed by Paul Ehrlich (1854–1915) to explain the immune response in living cells. Ehrlich theorized from very early in his career that chemical structure could be used to explain why the immune response occurred in reaction to infection .