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Parietal cells (also known as oxyntic cells) are epithelial cells in the stomach that secrete hydrochloric acid (HCl) and intrinsic factor. These cells are located in the gastric glands found in the lining of the fundus and body regions of the stomach. [ 1 ]
Diagram showing parts of the stomach. The human stomach can be divided into four sections, beginning at the cardia followed by the fundus, the body and the pylorus. [7] [8] The gastric cardia is where the contents of the esophagus empty from the gastroesophageal sphincter into the cardiac orifice, the opening into the gastric cardia.
Fundic glands found in the fundus and also in the body have another two cell types–gastric chief cells and parietal cells (oxyntic cells). Foveolar cells (surface mucous cells) are mucus-producing cells which cover the inside of the stomach, protecting it from the corrosive nature of gastric acid.
System Tissue Epithelium Subtype; circulatory: blood vessels: Simple squamous: endothelium: digestive: ducts of submandibular glands: simple columnar - digestive ...
The parietal cells in the fundus of the stomach, produce a glycoprotein called intrinsic factor which is essential for the absorption of vitamin B12. Vitamin B12 (cobalamin), is carried to, and through the stomach, bound to a glycoprotein secreted by the salivary glands – transcobalamin I also called haptocorrin, which protects the acid ...
The duct is lined by columnar cells, continuous with the epithelium lining the surface of the mucous membrane of the stomach, the tubes by shorter and more cubical cell which are finely granular. The glands contain mucous cells and G cells that secrete gastrin. [8] The pylorus also contains scattered parietal cells and neuroendocrine cells.
Serous membranes have two layers. The parietal layers of the membranes line the walls of the body cavity (pariet- refers to a cavity wall). The visceral layer of the membrane covers the organs (the viscera). Between the parietal and visceral layers is a very thin, fluid-filled serous space, or cavity. [4]
Several types of endocrine cells are found in the gastric glands. The pyloric glands contain gastrin -producing cells ( G cells ); this hormone stimulates acid production from the parietal cells. Enterochromaffin-like cells (ECLs), found in the oxyntic glands release histamine , which also is a powerful stimulant of the acid secretion.