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The p-methoxy group of apixaban connects to S1 pocket of FXa but does not appear to have any interaction with any residues in this region of FXa. The pyrazole N-2 nitrogen atom of apixaban interacts with Gln-192 and the carbonyl oxygen interacts with Gly-216. The phenyl lactam group of apixaban is positioned between Tyr-99 and Phe-174 and due ...
Apixaban is a highly selective, orally bioavailable, and reversible direct inhibitor of free and clot-bound factor Xa. Factor Xa catalyzes the conversion of prothrombin to thrombin, the final enzyme in the coagulation cascade that is responsible for fibrin clot formation. [ 28 ]
Verapamil is a class-IV antiarrhythmic and more effective than digoxin in controlling ventricular rate. [19] Verapamil is not listed as a first line antihypertensive agent by the guidelines provided by JAMA in JNC-8. [20] However, it may be used to treat hypertension if patient has co-morbid atrial fibrillation or other types of arrhythmia. [17 ...
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PDFtk (short for PDF Toolkit) is a toolkit for manipulating Portable Document Format (PDF) documents. [3] [4] It runs on Linux, Windows and macOS. [5] It comes in three versions: PDFtk Server (open-source command-line tool), PDFtk Free and PDFtk Pro (proprietary paid). [2] It is able to concatenate, shuffle, split and rotate PDF files.
ABBYY FineReader PDF is an optical character recognition (OCR) application developed by ABBYY. [ 2 ] [ 3 ] First released in 1993, the program runs on Microsoft Windows ( Windows 7 or later) and Apple macOS (10.12 Sierra or later).
Skeletal formula of verapamil. Phenylalkylamine calcium channel blockers are relatively selective for myocardium, reduce myocardial oxygen demand and reverse coronary vasospasm, and are often used to treat angina.
Trandolapril/verapamil (Tarka) [2] is an oral antihypertensive medication that combines a slow release formulation of verapamil hydrochloride, a calcium channel blocker, and an immediate release formulation of trandolapril, an ACE inhibitor. The patent, held by Abbott Laboratories, expired on February 24, 2015.