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The metanephrogenic blastema or metanephric blastema (or metanephric mesenchyme, or metanephric mesoderm) is one of the two embryological structures that give rise to the kidney, the other being the ureteric bud. The metanephric blastema mostly develops into nephrons, but can also form parts of the collecting duct system.
The collecting ducts descend again into the medulla and fuse to wider collecting ducts, which pass through the inner medulla. [ 68 ] [ 69 ] Based on the location of the renal corpuscle in the cortex, nephrons are classified into 3 types: superficial (closer to the renal capsule), midcortical (in the middle part of the cortex) and juxtamedullary ...
Metanephric adenoma (MA) is a rare, benign tumour of the kidney, that can have a microscopic appearance similar to a nephroblastoma (Wilms tumours), [1] or a papillary renal cell carcinoma. It should not be confused with the pathologically unrelated, yet similar sounding, mesonephric adenoma .
Each metanephric kidney is characterized by a large number of nephrons and a highly branched system of collecting tubules and ducts, [28] that open into the ureter. [48] Such branching in the metanephros is unique in relation to the pronephros and mesonephros. [ 44 ]
The collecting duct system of the kidney consists of a series of tubules and ducts that physically connect nephrons to a minor calyx or directly to the renal pelvis.The collecting duct participates in electrolyte and fluid balance through reabsorption and excretion, processes regulated by the hormones aldosterone and vasopressin (antidiuretic hormone).
The mechanism of multicystic dysplastic kidney is a result of an abnormal induction of metanephric mesenchyme. This could be a result of a formation difficulty of the mesonephric duct . Some mutations in genes associated with renal dysplasia (in syndromes) have been determined.
Gross appearance of a renal oncocytoma (left of image) and a slice of a normal kidney (right of image). Note the rounded contour, the mahogany colour and the central scar. In gross appearance, the tumors are tan or mahogany brown, well circumscribed and contain a central scar.
Metanephric dysplastic hematoma of the sacral region (MDHSR) has been described by Cozzutto and Lazzaroni-Fossati in 1980, [1] by Posalaki et al. in 1981 [2] and by Cozzutto et al. in 1982. [3] Three additional cases were seen by Finegold.