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Baclofen, sold under the brand name Lioresal among others, is a medication used to treat muscle spasticity, such as from a spinal cord injury or multiple sclerosis. [8] [9] It may also be used for hiccups and muscle spasms near the end of life, [9] and off-label to treat alcohol use disorder [10] [11] or opioid withdrawal symptoms. [12]
A drug is considered highly soluble when the highest dose strength is soluble in 250 ml or less of aqueous media over the pH range of 1 to 6.8. The volume estimate of 250 ml is derived from typical bioequivalence study protocols that prescribe administration of a drug product to fasting human volunteers with a glass of water.
Baclofen [71] or tizanidine are sometimes used as an alternative to benzodiazepines. Tizanidine has been found to have superior tolerability compared to diazepam and baclofen. [72] Benzodiazepines are also used to treat the acute panic caused by hallucinogen intoxication. [73]
"A typical dose of caffeine (100 mg) can be consumed up to 4 hours prior to bedtime without significant effect on subsequent sleep. To mitigate caffeine-induced sleep disruptions, it is ...
Doesn't do a thing to make them lay off the coke or meth, though, and hardcore users may use it at high dosages on a daily basis! Aadieu 08:59, 27 April 2010 (UTC) (outdent) The study for alcoholics was only 30 days long; baclofen was administered 12 - 24 hours after the last drink to alcohol dependent individuals or placebo.
The average check was only about $1,979 per month in January 2025. That adds up to less than $24,000 annually. Meanwhile, the average senior household spends just over $60,000 per year, according ...
A baclofen pump has been used to treat patients of all ages exhibiting muscle spasticity along with dystonia. The pump delivers baclofen via a catheter to the thecal space surrounding the spinal cord. The pump itself is placed in the abdomen. It can be refilled periodically by access through the skin. Baclofen can also be taken in tablet form [40]
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