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Salmeterol works by stimulating intracellular adenyl cyclase, which acts as a catalyst in the production of cyclic AMP. Increased cyclic AMP levels lead to a relaxation of bronchial smooth muscles. Additionally, cyclic AMP inhibits the release of mediators of immediate hypersensitivity. [2]
Salmeterol is a long-acting β 2 adrenergic receptor agonist (LABA) used in the treatment and prevention of asthma symptoms and control of chronic obstructive pulmonary disease (COPD) symptoms. [2] Symptoms of bronchospasm include shortness of breath , wheezing , coughing and chest tightness.
Inhaler for a powder based in budesonide and formoterol. Formoterol is marketed in three forms: a dry-powder inhaler (DPI), a metered-dose inhaler (MDI) and an inhalation solution, under various brand names including Atock, Atimos/Atimos Modulite, Foradil/Foradile, Fostair, Oxeze/Oxis, Perforomist and Symbicort.
He managed his symptoms with Advair Diskus — the brand name for fluticasone and salmeterol, ... including Advair Diskus formulary alternatives with member copays as low as $5.” ...
There were no asthma-related deaths and few asthma-related serious adverse events when salmeterol is used with an inhaled steroid. [ 5 ] [ 6 ] At least with formoterol , an increased risk appears to be present even when steroids are used [ 7 ] and this risk has not been ruled out for salmeterol.
It has a higher in vitro selectivity for β 2 receptors than the related drugs formoterol and salmeterol: 241-fold versus β 1 and 2299-fold versus β 3 adrenergic receptors. [5] The high β 2 /β 1 selectivity may account for the apparent lack of tachycardia in clinical trials, which is mediated by β 1 receptors on the heart.
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