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Eosinophilic granulomatosis with polyangiitis (EGPA), formerly known as allergic granulomatosis, [3] [4] is an extremely rare autoimmune condition that causes inflammation of small and medium-sized blood vessels in persons with a history of airway allergic hypersensitivity . [5] It usually manifests in three stages.
Apart from GPA, this category includes eosinophilic granulomatosis with polyangiitis (EGPA) and microscopic polyangiitis. [1] Although GPA affects small- and medium-sized vessels, [20] it is formally classified as one of the small-vessel vasculitides in the Chapel Hill system. [2]
The negative immunofluorescence pattern, however, is called "pauci-immune" and is often associated with systemic vasculitides (plural of vasculitis) including: microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (EGPA), and granulomatosis with polyangiitis (GPA).
Eosinophilic granulomatosis with polyangiitis is a systemic small-vessel vasculitis linked to eosinophilia and asthma. Polyneuropathy, cardiac involvement, skin lesions, involvement of the upper respiratory tract, and lung are typical presentations of eosinophilic granulomatosis with polyangiitis. [12] Granulomatosis with polyangiitis, formerly ...
Eosinophilic pneumonia can also occur when the immune system attacks the lungs, a disease called eosinophilic granulomatosis with polyangiitis. When a cause cannot be found, the eosinophilic pneumonia is termed "idiopathic". Idiopathic eosinophilic pneumonia can also be divided into acute and chronic forms, depending on the symptoms a person is ...
Microscopic polyangiitis is the most common cause of pulmonary-renal syndrome. [ citation needed ] Other causes include systemic lupus erythematosus , eosinophilic granulomatosis with polyangiitis , microscopic polyangiitis , dermatomyositis , polymyositis , mixed connective tissue disease , poststreptococcal glomerulonephritis , rheumatoid ...
Churg, together with Lotte Strauss, has given his name to Churg–Strauss syndrome, now known as eosinophilic granulomatosis with polyangiitis. [1] [2] Works
Due to the harmful role of eosinophils in diseases such as eosinophilic asthma and eosinophilic granulomatosis with polyangiitis, drugs have been developed to purposefully diminish eosinophils in order to alleviate symptoms. [8] Some examples of these drugs include mepolizumab, reslizumab, and benralizumab. [9]
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