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Haloperidol, sold under the brand name Haldol among others, is a typical antipsychotic medication. [9] Haloperidol is used in the treatment of schizophrenia , tics in Tourette syndrome , mania in bipolar disorder , delirium , agitation, acute psychosis , and hallucinations from alcohol withdrawal .
Haloperidol decanoate is provided in the form of 50 or 100 mg/mL oil solution of sesame oil and benzyl alcohol in ampoules or pre-filled syringes. [6] [7] [9] Its elimination half-life after multiple doses is 21 days. [10] [11] The medication is marketed in many countries throughout the world. [3] [12
HPP + is formed from haloperidol, and its dehydration product HPTP, by CYP3A enzymes in the liver. [ 1 ] [ 2 ] [ 4 ] The compound can cross the blood–brain barrier and has been detected in the brain following haloperidol administration in both animals and humans.
If a scheduled injection of either haloperidol decanoate or fluphenazine decanoate is missed, recommendations for administering make-up injectable dose(s) or providing antipsychotics to be taken by mouth vary by, e.g., how long ago the last injection was and how many previous injections the person has received (i.e., if steady state levels of ...
High-potency antipsychotics such as haloperidol, in general, have doses of a few milligrams and cause less sleepiness and calming effects than low-potency antipsychotics such as chlorpromazine and thioridazine, which have dosages of several hundred milligrams. The latter have a greater degree of anticholinergic and antihistaminergic activity ...
[22] [23] Companies like CVS and Express Scripts in the US have begun implementing pricing based on indication [24] and in countries like Italy, similar forms of pricing are already being used. [15] [25] For example, Express Scripts' "Oncology Care Value Program," uses indication-based pricing for certain oncology medications and was launched ...
Dopamine receptor flow chart. Dopamine receptors are all G protein–coupled receptors, and are divided into two classes based on which G-protein they are coupled to. [1] The D 1-like class of dopamine receptors is coupled to Gα s/olf and stimulates adenylate cyclase production, whereas the D 2-like class is coupled to Gα i/o and thus inhibits adenylate cyclase production.
Concerta (methylphenidate) – an extended release form of methylphenidate Contrave ( naltrexone/bupropion ) – a combination drug used in the treatment of mood and psychotic disorders. It is also approved for weight loss in those that are either obese or overweight with some weight-related illnesses