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Phenibut is used in Russia, Ukraine, Belarus and Latvia as a pharmaceutical drug to treat anxiety and to improve sleep (e.g., in the treatment of insomnia). [5] [6] It is also used for various other indications, including the treatment of asthenia, depression, alcoholism, alcohol withdrawal syndrome, post-traumatic stress disorder, stuttering, tics, vestibular disorders, Ménière's disease ...
An assortment of several designer drugs. Designer drugs are structural or functional analogues of controlled substances that are designed to mimic the pharmacological effects of the parent drug while avoiding detection or classification as illegal.
4-Fluorophenibut (developmental code name CGP-11130; also known as β-(4-fluorophenyl)-γ-aminobutyric acid or β-(4-fluorophenyl)-GABA) is a GABA B receptor agonist which was never marketed. [1]
Glufimet (dimethyl 3-phenylglutamate hydrochloride) – experimental drug related to phenibut; Glutamic acid (glutamate) – neurotransmitter; Homotaurine (tramiprosate) – GABA A receptor agonist, GABA B receptor antagonist; Hopantenic acid (N-pantoyl-GABA) – central nervous system depressant used in Russia
As part of the plea, [the defendant] has agreed to forfeit $2.4 million. [The defendant] has also agreed to forfeit all tianeptine, adrafinil, phenibut, and racetams seized by the FDA and Customs and Border Protection. FDA has not approved drugs containing tianeptine, adrafinil, phenibut, and racetams for use in the United States.
Cross-tolerance is a phenomenon that occurs when tolerance to the effects of a certain drug produces tolerance to another drug. It often happens between two drugs with similar functions or effects—for example, acting on the same cell receptor or affecting the transmission of certain neurotransmitters.
4. I don't need an example of a supplement containing Phenibut in the US, also not specific to supplement as you could have a non-dietary ingredient in food or beverages. The fact is that a company can lawfully get a self affirmed GRAS for a condition of use and lawfully market Phenibut as a component of a supplement, food, bev. 5.
In one study, the affinity (K i) values of gabapentinoids for the α 2 δ subunit expressed in rat brain were found to be 0.05 μM for gabapentin, 23 μM for (R)-phenibut, 39 μM for (S)-phenibut, and 156 μM for baclofen. [9] Their affinities (K i) for the GABA B receptor were >1 mM for gabapentin, 92 μM for (R)-phenibut, >1 mM for (S)-phenibut.