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It was discovered in 2000 as one of two improved mutants by H. Bujard and his colleagues after random mutagenesis of the Tet repressor part of the transactivator gene. [6] Tet-On 3G (also known as rtTA-V10 [7]) is similar to Tet-On Advanced but was derived from rtTA2 S-S2 rather than rtTA2 S-M2. It is also human codon optimized and composed of ...
The transactivator gene expresses a transcription factor that binds to specific promoter region of DNA. By binding to the promoter region of a gene, the transcription factor causes that gene to be expressed. The expression of one transactivator gene can activate multiple genes, as long as they have the same, specific promoter region attached.
The book is aimed at a "general mathematical audience" [1] including undergraduate mathematics students with an introductory-level background in real analysis. [2] It is intended both to excite mathematicians, physicists, and computer scientists about the foundational issues in their fields, [6] and to provide an accessible introduction to the subject.
Thus TET enzymes largely initiate demethylation at 5mCpG sites. Oxoguanine glycosylase (OGG1) is one example of a protein that recruits a TET enzyme. TET1 is able to act on 5mCpG if an ROS has first acted on the guanine to form 8-hydroxy-2'-deoxyguanosine (8-OHdG or its tautomer 8-oxo-dG), resulting in a 5mCp-8-OHdG dinucleotide (see Figure). [10]
[2] [3] Binding of the activator-coactivator complex increases the speed of transcription by recruiting general transcription machinery to the promoter, therefore increasing gene expression. [ 3 ] [ 4 ] [ 5 ] The use of activators and coactivators allows for highly specific expression of certain genes depending on cell type and developmental stage.
Reverse mathematics is a program in mathematical logic that seeks to determine which axioms are required to prove theorems of mathematics. Its defining method can briefly be described as "going backwards from the theorems to the axioms ", in contrast to the ordinary mathematical practice of deriving theorems from axioms.
The version given here is that proven by Nash-Williams; Kruskal's formulation is somewhat stronger. All trees we consider are finite. Given a tree T with a root, and given vertices v, w, call w a successor of v if the unique path from the root to w contains v, and call w an immediate successor of v if additionally the path from v to w contains no other vertex.
A user will input a number and the Calculator will use an algorithm to search for and calculate closed-form expressions or suitable functions that have roots near this number. Hence, the calculator is of great importance for those working in numerical areas of experimental mathematics. The ISC contains 54 million mathematical constants.