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Inner ear regeneration is the biological process by which the hair cells and supporting cells (i.e. Hensen's cells and Deiters cells) of the ear proliferate (cell proliferation) and regrow after hair cell injury. This process depends on communication between supporting cells and the brain.
[5] [6] Furthermore, Hensen's cells are also able to regenerate the damaged hair cells in some vertebrates; they undergo phagocytosis to eject the dead or injured hair cells, and reproduce both new hair cells and supporting cells into the cell cycle. One of the reasons is that the supporting cells are differentiated by the embryonic hair cells ...
The cell cycle inhibitor p27kip1 has also been found to encourage regrowth of cochlear hair cells in mice following genetic deletion or knock down with siRNA targeting p27. [36] [37] Research on hair cell regeneration may bring us closer to clinical treatment for human hearing loss caused by hair cell damage or death.
The height of hair bundles increases from base to apex and the number of stereocilia decreases (i.e. hair cells located at the base of the cochlea contain more stereo cilia than those located at the apex). [14] Furthermore, in the tip-link complex of cochlear hair cells, tonotopy is associated with gradients of intrinsic mechanical properties. [15]
The outer hair cells, instead, mainly 'receive' neural input from the brain, which influences their motility as part of the cochlea's mechanical "pre-amplifier". The input to the OHC is from the olivary body via the medial olivocochlear bundle. The cochlear duct is almost as complex on its own as the ear itself.
The olivocochlear system is a component of the auditory system involved with the descending control of the cochlea.Its nerve fibres, the olivocochlear bundle (OCB), form part of the vestibulocochlear nerve (VIIIth cranial nerve, also known as the auditory-vestibular nerve), and project from the superior olivary complex in the brainstem to the cochlea.
Hearing: Cochlear duct: fluid waves in the endolymph of the cochlear duct stimulate the receptor cells, which in turn translate their movement into nerve impulses that the brain perceives as sound. Balance: Semicircular canals: angular acceleration of the endolymph in the semicircular canals stimulate the vestibular receptors of the endolymph.
It is separated from the cochlear duct by the basilar membrane, and it extends from the round window to the helicotrema, where it continues as vestibular duct. The purpose of the perilymph-filled tympanic duct and vestibular duct is to transduce the movement of air that causes the tympanic membrane and the ossicles to vibrate causing movement ...
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