Search results
Results From The WOW.Com Content Network
An aldol condensation is a condensation reaction in organic chemistry in which two carbonyl moieties (of aldehydes or ketones) react to form a β-hydroxyaldehyde or β-hydroxyketone (an aldol reaction), and this is then followed by dehydration to give a conjugated enone.
The aldol reaction (aldol addition) is a reaction in organic chemistry that combines two carbonyl compounds (e.g. aldehydes or ketones) to form a new β-hydroxy carbonyl compound. Its simplest form might involve the nucleophilic addition of an enolized ketone to another:
Intramolecular aldol condensation is between two aldehyde groups or ketone groups in the same molecule. Five- or six-membered α , β -unsaturated ketone or aldehydes are formed as products. This reaction is an important approach to the formation of carbon-carbon bonds in organic molecules containing ring systems.
Condensation reactions likely played major roles in the synthesis of the first biotic molecules including early peptides and nucleic acids. In fact, condensation reactions would be required at multiple steps in RNA oligomerization: the condensation of nucleobases and sugars , nucleoside phosphorylation , and nucleotide polymerization.
In organic chemistry, an aldol is a structure consisting of a hydroxy group (-OH) two carbons away from either an aldehyde or a ketone. The name combines the suffix 'ol' from the alcohol and the prefix depending on the carbonyl group , either 'ald' for an aldehyde, or 'ket' for a ketone, in which case it referred to as a 'ketol'.
Chalcone is usually prepared by an aldol condensation between benzaldehyde and acetophenone. [ 6 ] This reaction, which can be carried out without any solvent, is so reliable that it is often given as an example of green chemistry in undergraduate education.
Aldol reactions are a key reaction in organic chemistry because they provide a means of forming carbon-carbon bonds, allowing for the synthesis of more complex molecules. [ 9 ] An aldol condensation reaction is one of the most common examples of an E1cB mechanism.
Condensation of α,β-unsaturated aldehyde 22 with the organocatalyst then facilitates the conjugate addition of 25 to give intermediate enamine 26, which is prone to undergo an intramolecular aldol condensation to iminium species 27. Organocatalyst 23 is regenerated by hydrolysis, along with the product 24, thus closing the triple cascade ...