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Effects generally begin within three hours and last for up to three days. [2] Long-term treatment with chlortalidone is more effective than hydrochlorothiazide for prevention of heart attack or stroke. [5] Common adverse effects include low blood potassium, low blood sodium, high blood sugar, dizziness, and erectile dysfunction.
It is a type of photosensitivity. [1] [2] The skin response resembles an exaggerated sunburn. The involved chemical may enter into the skin by topical administration, or it may reach the skin via systemic circulation following ingestion or parenteral administration. The chemical needs to be "photoactive," which means that when it absorbs light ...
Typical peak tumour accumulation levels post-administration for PPIX are usually achieved within several hours; other (intravenous) photosensitisers may take up to 96 hours to reach peak levels. ALA is also excreted more rapidly from the body (~24 hours) than other photosensitisers, minimising photosensitivity side effects. [3]
Photosensitivity is the amount to which an object reacts upon receiving photons, especially visible light. In medicine, the term is principally used for abnormal reactions of the skin, and two types are distinguished, photoallergy and phototoxicity .
"Chlortalidone has a higher risk of side effects than hydrochlorothiazide." [1] Quote = However, chlorthalidone use is more frequently associated with adverse metabolic effects, particularly hypokalemia and hyponatremia, compared with HCTZ. Doc James (talk · contribs · email) 09:34, 2 November 2019 (UTC) Agreed. That ref is clear.
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The thiazide-like diuretics (indapamide and chlorthalidone) reduce risk of major cardiovascular events and heart failure in hypertensive patients compared with hydrochlorothiazide with a comparable incidence of adverse events. [5] Both thiazide diuretics and thiazide-like diuretics are effective in reducing risk of stroke.
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