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Roth's spots, also known as Litten spots or the Litten sign, [1] are non-specific red lesions with white or pale centres, seen on the retina of the eye and although traditionally associated with infective endocarditis, can occur in a number of other conditions including hypertension, diabetes, collagen vascular disease, extreme hypoxia, leukemia and HIV.
The nodes are commonly indicative of subacute bacterial endocarditis. [3] 10–25% of endocarditis patients will have Osler's nodes. [4] Other signs of endocarditis include Roth's spots and Janeway lesions. The latter, which also occur on the palms and soles, can be differentiated from Osler's nodes because they are non-tender. [2]
Litten's sign is a clinical sign in which cotton wool spots are seen on fundoscopic examination of the retina in patients with infective endocarditis. [ 1 ] The sign is named after Moritz Litten .
Another form of sterile endocarditis is termed Libman–Sacks endocarditis; this form occurs more often in patients with lupus erythematosus and is thought to be due to the deposition of immune complexes. [2] Like NBTE, Libman-Sacks endocarditis involves small vegetations, while infective endocarditis is composed of large vegetations. [2]
Infective endocarditis is associated with 18% in-hospital mortality. [24] However, adult patients with congenital heart disease can have relatively lower mortality down to 5% due to younger age, right-sided endocarditis and management by multidisciplinary teams. As many as 50% of people with infective endocarditis may experience embolic ...
The Getty Villa art museum is threatened by the flames of the wind-driven Palisades Fire in Pacific Palisades, California, Jan. 7, 2025. A fast-moving brushfire in a Los Angeles suburb burned ...
in the eye these deposits can lead to Roth spots, and in the kidney they can lead to glomerulonephritis. Diagnosing the cause of infective endocarditis, typically involves getting positive blood culture, which is literally growing bacteria from a blood sample.
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