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This is a list of investigational autism and pervasive developmental disorder drugs, or drugs that are currently under development for clinical use in the treatment of autistic spectrum disorders and/or other pervasive developmental disorders but are not yet approved.
Dibenzazepine (iminostilbene) is a chemical compound with two benzene rings fused to an azepine ring. [1] Many pharmaceuticals, such as carbamazepine , oxcarbazepine , and depramine , are based on a dibenzazepine structure.
Autism spectrum disorder [a] (ASD), or simply autism, is a neurodevelopmental disorder "characterized by persistent deficits in social communication and social interaction across multiple contexts" and "restricted, repetitive patterns of behavior, interests, or activities". [11]
Dibenzepin, sold under the brand name Noveril among others, is a tricyclic antidepressant (TCA) used widely throughout Europe for the treatment of depression. [ 2 ] [ 3 ] [ 4 ] It has similar efficacy and effects relative to other TCAs like imipramine but with fewer side effects .
About 10–15% of autism cases have an identifiable Mendelian (single-gene) condition, chromosome abnormality, or other genetic syndrome, [6] a category referred to as syndromic autism. Approximately 8 in 10 people with autism suffer from a mental health problem in their lifetime, in comparison to 1 in 4 of the general population that suffers ...
Historically, "conventional" pharmacotherapy has been used to reduce behaviors and sensitivities associated with ASD. [13] Many such treatments have been prescribed off-label in order to target specific symptoms. [14] Today, medications are primarily prescribed to adults with autism to avoid any adverse effects in the developing brains of children.
Autistic meltdown describes an intense, often uncontrollable response to an overwhelming situation experienced by some autistic individuals.. Angry outbursts in autistic people have been referred to as meltdowns that manifest as an intense reaction, [1] but such outbursts are different to true meltdowns, which always take some time to recover from. [2]
The TCAs are used primarily in the clinical treatment of mood disorders such as major depressive disorder (MDD), dysthymia, and treatment-resistant variants. They are also used in the treatment of a number of other medical disorders, including cyclic vomiting syndrome (CVS) and anxiety disorders such as generalized anxiety disorder (GAD), social phobia (SP) also known as social anxiety ...