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Methocarbamol, sold under the brand name Robaxin among others, is a medication used for short-term musculoskeletal pain. [3] [4] It may be used together with rest, physical therapy, and pain medication. [3] [5] [6] It is less preferred in low back pain. [3] It has limited use for rheumatoid arthritis and cerebral palsy.
Eperisone hydrochloride is available as the brand name preparations Myonal and Epry as 50 mg sugar-coated tablets, or as 10% granules for oral administration. [6] An experimental form of the drug, as a transdermal patch system, has shown promising results in laboratory tests on rodents; however, this product is not currently available for human use.
Contraindicated in pregnancy: Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.
WHO recommends taking supplements of 30–60 mg of elemental iron a day throughout pregnancy for all pregnant individuals. Iron demand depends on individual specific factors and risk of deficiency; for specific dose recommendations, individuals should discuss with their doctors. [65]
[5] Other common spasmolytic agents include: methocarbamol, carisoprodol, chlorzoxazone, cyclobenzaprine, gabapentin, metaxalone, and orphenadrine. Thiocolchicoside is a muscle relaxant with anti-inflammatory and analgesic effects and an unknown mechanism of action.
Methocarbamol is also used in the treatment of tetanus (which is characterized by muscle rigidity) and strichnine poisoning (characterized by stiffness and seizuring). In cats, methocarbamol is an important medication in the treatment of permethrin poisoning (which occurs when canine permethrin flea products are used inadvertantly on pet cats.)
Meprobamate—marketed as Miltown by Wallace Laboratories and Equanil by Wyeth, among others—is a carbamate derivative used as an anxiolytic drug. It was the best-selling minor tranquilizer for a time, but has largely been replaced by the benzodiazepines due to their wider therapeutic index (lower risk of toxicity at therapeutically prescribed doses) and lower incidence of serious side effects.
It is a recommended treatment in pregnancy and appears to be safe for the baby. [4] [5] The World Health Organization; however, recommends waiting until after pregnancy for treatment when feasible. [2] It is made from 4-methyl-piperazine. [6] Diethylcarbamazine was discovered in 1947 [7] by Yellapragada Subbarow.