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Copy number analysis is the process of analyzing data produced by a test for DNA copy number variation in an organism's sample. One application of such analysis is the detection of chromosomal copy number variation that may cause or may increase risks of various critical disorders.
Copy number variation (CNV) is a phenomenon in which sections of the genome are repeated and the number of repeats in the genome varies between individuals. [1] Copy number variation is a type of structural variation: specifically, it is a type of duplication or deletion event that affects a considerable number of base pairs. [2]
Query by Example (QBE) is a database query language for relational databases. It was devised by Moshé M. Zloof at IBM Research during the mid-1970s, in parallel to the development of SQL . [ 1 ] It is the first graphical query language, using visual tables where the user would enter commands, example elements and conditions.
Homogeneously staining regions (HSRs) are chromosomal segments with various lengths and uniform staining intensity after G banding.This type of aberration is also known as Copy Number Gains or Amplification.
Multiplex ligation-dependent probe amplification (MLPA) is a variation of the multiplex polymerase chain reaction that permits amplification of multiple targets with only a single primer pair. [1] It detects copy number changes at the molecular level, and software programs are used for analysis.
For example, pBR322 is a medium copy number plasmid (~20 copies/cell) from which several high copy number cloning vectors (>100 copies/cell) have been derived by mutagenesis, such as the well known pUC series. [1] This delivers the convenience of high plasmid DNA yields but the additional burden of the high copy number restricts the plasmid size.
The SQL/Schemata, or Information and Definition Schemas, part of the SQL standard is defined by ISO/IEC 9075-11:2008. SQL/Schemata defines the information schema and definition schema , providing a common set of tools to make SQL databases and objects self-describing.
W3Schools is a freemium educational website for learning coding online. [ 1 ] [ 2 ] Initially released in 1998, it derives its name from the World Wide Web but is not affiliated with the W3 Consortium .