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Isotopocules are isotopically substituted molecules, which differ only in their isotopic composition or their isotopes' intramolecular position. [1] "Isotopocule" is also an umbrella term for the more specific terms "isotopologue" and "isotopomer", coined by Jan Kaiser and Thomas Röckmann in 2008. [2] [3]
An early application of isotope dilution in the form of radiotracer method was determination of the solubility of lead sulphide and lead chromate in 1913 by George de Hevesy and Friedrich Adolf Paneth. [2] In the 1930s, US biochemist David Rittenberg pioneered the use of isotope dilution in biochemistry enabling detailed studies of cell ...
Depending on the formula and the symmetry of the structure, there might be several isotopomers of one isotopologue. For example, ethanol has the molecular formula C 2 H 6 O. Mono-deuterated ethanol, C 2 H 5 DO or C 2 H 5 2 HO, is an isotopologue of it. The structural formulas CH 3 −CH 2 −O−D and CH 2 D−CH 2 −O−H are two isotopomers ...
Advanced Placement (AP) Biology (also known as AP Bio) is an Advanced Placement biology course and exam offered by the College Board in the United States. For the 2012–2013 school year, the College Board unveiled a new curriculum with a greater focus on "scientific practices".
H NMR spectrum of a solution of HD (labeled with red bars) and H 2 (blue bar). The 1:1:1 triplet arises from the coupling of the 1 H nucleus (I = 1/2) to the 2 H nucleus (I = 1). In NMR spectroscopy, isotopic effects on chemical shifts are typically small, far less than 1 ppm, the typical unit for measuring shifts. The 1 H NMR signals for 1 H 2 ...
Isotope separation is the process of concentrating specific isotopes of a chemical element by removing other isotopes. The use of the nuclides produced is varied. The largest variety is used in research (e.g. in chemistry where atoms of "marker" nuclide are used to figure out reaction mechanisms).
Archaeological materials, such as bone, organic residues, hair, or sea shells, can serve as substrates for isotopic analysis. Carbon, nitrogen and zinc isotope ratios are used to investigate the diets of past people; these isotopic systems can be used with others, such as strontium or oxygen, to answer questions about population movements and cultural interactions, such as trade.
It is used for diagnoses involving a large range of body parts and diseases such as cancers and neurological problems. [1] Another well-known radioactive isotope used in medicine is Iodine-131 , which is used as a radioactive label for some radiopharmaceutical therapies or the treatment of some types of thyroid cancer.