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Compared to 89 individuals (median age 59.1 years) with a similar distribution of their UPS tumors, individuals with the neoplastic syndrome had similar tumor recurrence rates (57.14% vs 53.93% for the two respective groups) but a lower metastasis rate (14.29% vs 44.94%) and a higher 3-year survival rate (85.71% vs 59.55%).
Pediatric rhabdomyosarcoma patients have a 50–85% long term survival rate. [23] Osteosarcoma is a cancer of the bone that is treated with surgical resection of as much of the cancer as possible, often along with chemotherapy. [24] Radiotherapy is a second alternative to surgery, although not as successful.
In one series, the median age of affected individuals was 45 years, with a 10-year survival rate of 70 percent. [1] In another study, age over 45 and female sex were associated with worse survival rates in hemangiopericytomas. [9]
Sarcoma: Adolescents and young adults often fare worse than young children with the same histologic type of sarcoma. In Ewing sarcoma, survival is inversely related to age and tumor size diagnosis. Adolescents and young adults with rhabdomyosarcoma have a much lower survival rate at 5 years than children, 27% compared with 61%. [15]
In fact, multi-agent chemotherapy is indicated for all patients with rhabdomyosarcoma. Before the use of adjuvant and neoadjuvant therapy involving chemotherapeutic agents, treatment solely by surgical means had a survival rate of <20%. Modern survival rates with adjuvant therapy are approximately 60–70%. [8] [39]
As a novel form of treatment used in other cancers, immunotherapy may have a role in treating soft-tissue sarcomas like alveolar soft part sarcoma and pleomorphic undifferentiated sarcoma. However, as of 2023, only alveolar soft part sarcoma has a regulatory approval for such an agent, in this case atezolizumab. [19]
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