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Although neurosyphilis is a neurological disease, neuropsychiatric symptoms might appear due to overall damage to the brain. These symptoms can make the diagnosis more difficult and can include symptoms of dementia , [ 10 ] [ 11 ] mania , psychosis , depression , [ 12 ] and delirium : [ 13 ]
The symptoms arise as a result of inflamed meninges, which eventually lead up to signs of meningitis. [2] Treponema pallidum invades the nervous system within three to eighteen months after the primary infection. The initial series of events is asymptomatic meningitis, which can remain in the human body system and produce more damage within the ...
Involvement of the central nervous system in syphilis (either asymptomatic or symptomatic) can occur at any stage of the infection. [21] It may occur early, being either asymptomatic or in the form of syphilitic meningitis ; or late as meningovascular syphilis, manifesting as general paresis or tabes dorsalis .
General paresis, also known as general paralysis of the insane (GPI), paralytic dementia, or syphilitic paresis is a severe neuropsychiatric disorder, classified as an organic mental disorder, and is caused by late-stage syphilis and the chronic meningoencephalitis and cerebral atrophy that are associated with this late stage of the disease when left untreated.
Syphilis can attack any organ system and can cause long-term damage to the heart, brain, nerves and eyes, according to the Cleveland Clinic. Dating trends that increase STI risk
A complication of tabes dorsalis can be transient neuralgic paroxysmal pain affecting the eyes and the ophthalmic areas, previously called "Pel's crises" after Dutch physician P.K. Pel. Now more commonly called "tabetic ocular crises", an attack is characterized by sudden, intense eye pain, tearing of the eyes and sensitivity to light .
Quality sleep is crucial for brain health. Past research has shown that proper sleep can have a positive impact on the brain’s glymphatic system and its ability to clear out waste. Piantino and ...
Untreated, it can lead to complications and death. [67] Clinical manifestations of syphilis include the ulceration of the uro-genital tract, mouth or rectum; if left untreated the symptoms worsen. In recent years, the prevalence of syphilis has declined in Western Europe, but it has increased in Eastern Europe (former Soviet states).