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Several nano-delivery drugs were on the market by 2019. [17] Drug delivery systems, lipid-[18] or polymer-based nanoparticles, can be designed to improve the pharmacokinetics and biodistribution of the drug. [19] [20] [21] However, the pharmacokinetics and pharmacodynamics of nanomedicine is highly variable among different patients. [22]
Nanoparticle drug delivery systems are engineered technologies that use nanoparticles for the targeted delivery and controlled release of therapeutic agents. The modern form of a drug delivery system should minimize side-effects and reduce both dosage and dosage frequency. Recently, nanoparticles have aroused attention due to their potential ...
This means of delivery is largely founded on nanomedicine, which plans to employ nanoparticle-mediated drug delivery in order to combat the downfalls of conventional drug delivery. These nanoparticles would be loaded with drugs and targeted to specific parts of the body where there is solely diseased tissue, thereby avoiding interaction with ...
Nanoparticles for drug delivery to the brain is a method for transporting drug molecules across the blood–brain barrier (BBB) using nanoparticles. These drugs cross the BBB and deliver pharmaceuticals to the brain for therapeutic treatment of neurological disorders.
Nanocarriers range from sizes of diameter 1–1000 nm, [3] [4] however due to the width of microcapillaries being 200 nm, nanomedicine often refers to devices <200 nm. [4] Because of their small size, nanocarriers can deliver drugs to otherwise inaccessible sites around the body.
Drug delivery systems have been around for many years, but there are a few recent applications of drug delivery that warrant 1. Drug delivery to the brain: Many drugs can be harmful when administered systemically; the brain is very sensitive to medications and can easily cause damage if a drug is administered directly into the bloodstream.
A common application of nanomedicine is in therapeutic drug delivery, where nanoparticles containing drugs for therapeutic treatment of disease are introduced into the body and act as vessels that deliver the drugs to the targeted area.
Moein Moghimi is a British professor and researcher in the fields of nanomedicine, drug delivery and biomaterials. He is currently the professor of Pharmaceutics and Nanomedicine at the School of Pharmacy and the Translational and Clinical Research Institute at Newcastle University.