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  2. DNA replication - Wikipedia

    en.wikipedia.org/wiki/DNA_replication

    Eukaryotes initiate DNA replication at multiple points in the chromosome, so replication forks meet and terminate at many points in the chromosome. Because eukaryotes have linear chromosomes, DNA replication is unable to reach the very end of the chromosomes. Due to this problem, DNA is lost in each replication cycle from the end of the chromosome.

  3. Primase - Wikipedia

    en.wikipedia.org/wiki/Primase

    DNA primase is an enzyme involved in the replication of DNA and is a type of RNA polymerase. Primase catalyzes the synthesis of a short RNA (or DNA in some living organisms [ 1 ] ) segment called a primer complementary to a ssDNA (single-stranded DNA) template.

  4. Eukaryotic DNA replication - Wikipedia

    en.wikipedia.org/wiki/Eukaryotic_DNA_replication

    These origins of replication direct the number of protein complexes that will form to initiate replication. In bacterial DNA replication, regulation focuses on the binding of the DnaA initiator protein to the DNA, with initiation of replication occurring multiple times during one cell cycle. [93]

  5. DNA polymerase - Wikipedia

    en.wikipedia.org/wiki/DNA_polymerase

    A DNA polymerase is a member of a family of enzymes that catalyze the synthesis of DNA molecules from nucleoside triphosphates, the molecular precursors of DNA. These enzymes are essential for DNA replication and usually work in groups to create two identical DNA duplexes from a single original DNA duplex. During this process, DNA polymerase ...

  6. DnaG - Wikipedia

    en.wikipedia.org/wiki/DnaG

    DnaG (DNA primase) is an essential enzyme involved in the DNA replication fork Organic mechanism of oligonucleotide synthesis of ribonucleic acid (RNA) in the 5' to 3' direction DnaG catalyzes the synthesis of oligonucleotides in five discrete steps: template binding, nucleoside triphosphate (NTP) binding, initiation, extension to form a primer ...

  7. DNA polymerase I - Wikipedia

    en.wikipedia.org/wiki/DNA_polymerase_I

    DNA polymerase I (or Pol I) is an enzyme that participates in the process of prokaryotic DNA replication. Discovered by Arthur Kornberg in 1956, [ 1 ] it was the first known DNA polymerase (and the first known of any kind of polymerase ).

  8. DNA polymerase III holoenzyme - Wikipedia

    en.wikipedia.org/wiki/DNA_polymerase_III_holoenzyme

    DNA polymerase III synthesizes base pairs at a rate of around 1000 nucleotides per second. [3] DNA Pol III activity begins after strand separation at the origin of replication. Because DNA synthesis cannot start de novo, an RNA primer, complementary to part of the single-stranded DNA, is synthesized by primase (an RNA polymerase): [citation ...

  9. DnaA - Wikipedia

    en.wikipedia.org/wiki/DnaA

    DnaA is a protein that activates initiation of DNA replication in bacteria. [1] Based on the Replicon Model, a positively active initiator molecule contacts with a particular spot on a circular chromosome called the replicator to start DNA replication. [2] It is a replication initiation factor which promotes the unwinding of DNA at oriC. [1]