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Folate deficiency. Folate deficiency, also known as vitamin B9 deficiency, is a low level of folate and derivatives in the body. [1] This may result in megaloblastic anemia in which red blood cells become abnormally large, and folate deficiency anemia is the term given for this medical condition. [3] Signs of folate deficiency are often subtle. [4]
Cerebral folate deficiency. Cerebral folate deficiency is a condition in which concentrations of 5-methyltetrahydrofolate are low in the brain as measured in the cerebral spinal fluid despite being normal in the blood. [3] Symptoms typically appear at about 5 to 24 months of age. [3][2] Without treatment there may be poor muscle tone, trouble ...
Victor Herbert (hematologist) (Redirected from Victor Herbert (Hematologist)) Victor Herbert (February 22, 1927 – November 19, 2002) [1] was an American hematologist who did ground-breaking work on folate and how its deficiency led to megaloblastic anemia and was a proponent of accurate and responsible nutrition information. [2][3]
Folate deficiency can be caused by unhealthy diets that do not include enough vegetables and other folate-rich foods; diseases in which folates are not well absorbed in the digestive system (such as Crohn's disease or celiac disease); some genetic disorders that affect levels of folate; and certain medicines (such as phenytoin, sulfasalazine ...
The link between levels of folate and altered mental function is not large, but is sufficient enough to suggest a causal association. [23] Deficiency in folate can cause an elevation of homocysteine within the blood, [24] as the clearance of homocysteine requires enzymatic action dependent on folate, and to a lesser extent, vitamins B 6 and B 12.
Folate (aka Folic Acid) and Cobolamin are often grouped together, as vitamin B12 is made essential due to its role in cleaving methyltetrahydrofolate molecules to release active folate, without which a functional folate deficiency occurs [5]. Folate is required for the folate cycle, so deficiency prompts the down-regulation of nucleic acid ...
Specialty. Hematology. Hereditary spherocytosis (HS) is a congenital hemolytic disorder wherein a genetic mutation coding for a structural membrane protein phenotype causes the red blood cells to be sphere-shaped (spherocytosis), rather than the normal biconcave disk shape. This abnormal shape interferes with the cells' ability to flex during ...
As folate is vital in the first trimester of pregnancy for healthy fetal development, the use of antifolates is strongly contraindicated in pregnancy and carries significant teratogenic risk. Low doses of methotrexate can deplete folate stores and cause side-effects that are similar to folate deficiency. Both high-folate diets and supplemental ...