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In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to a specific DNA sequence. [1][2] The function of TFs is to regulate—turn on and off—genes in order to make sure that they are ...
A transcription factor is a protein that binds to specific DNA sequences (enhancer or promoter), either alone or with other proteins in a complex, to control the rate of transcription of genetic information from DNA to messenger RNA by promoting (serving as an activator) or blocking (serving as a repressor) the recruitment of RNA polymerase. [3 ...
SP1 belongs to the Sp/KLF family of transcription factors. The protein is 785 amino acids long, with a molecular weight of 81 kDa. The SP1 transcription factor contains two glutamine-rich activation domains at its N-terminus that are believed to be necessary for promoter trans -activation. [6] SP1 most notably contains three zinc finger protein ...
General transcription factors bind to the promoter. When a transcription factor is activated by a signal (here indicated as phosphorylation shown by a small red star on a transcription factor on the enhancer) the enhancer is activated and can now activate its target promoter. The active enhancer is transcribed on each strand of DNA in opposite ...
ETS transcription factor family. Structure of Ets-1 DNA binding autoinhibition. [1] In the field of molecular biology, the ETS (E26 transformation-specific[2] or E-twenty-six. (Erythroblast Transformation Specific)[3]) family is one of the largest families of transcription factors and is unique to animals. There are 28 genes in humans [4], 27 ...
This list of manually curated human transcription factors is taken from Lambert, Jolma, Campitelli et al. [1] It was assembled by manual curation. More detailed information is found in the manuscript and the web site accompanying the paper ( Human Transcription Factors )
After escaping the promoter and shedding most of the transcription factors for initiation, the polymerase acquires new factors for the next phase of transcription: elongation. [21] [22] Transcription elongation is a processive process. Double stranded DNA that enters from the front of the enzyme is unzipped to avail the template strand for RNA ...
transcriptional regulation – controlling the rate of gene transcription for example by helping or hindering RNA polymerase binding to DNA. transcription – the process of making RNA from a DNA template by RNA polymerase. transcription factor – a substance, such as a protein, that contributes to the cause of a specific biochemical reaction ...