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Ch. Fiacre's First and Foremost (born 9 September 2007), also known as Fiona, is a Dalmatian bred to have low levels of uric acid.She is registered to the United Kennel Club Dalmatian Breed Club in America and was registered with the American Kennel Club in 2011, when LUA Dalmatians were granted entry into the AKC.
Urate stones can be dissolved using a diet with reduced purines that alkalinizes and dilutes the urine. Allopurinol is used in dogs with altered purine metabolism to prevent the formation of uric acid. Feeding a diet high in purines while simultaneously administering allopurinol can result in the formation of xanthine (C 5 H 4 N 4 O 2) stones.
The Dalmatian is a breed of dog with a white coat marked with dark-coloured spots. Originally bred as a hunting dog , [ 2 ] it was also used as a carriage dog in its early days. The origins of this breed can be traced back to Croatia and its historical region of Dalmatia .
Media in category "Purines" This category contains only the following file. Fgams ppat egfp puncta.png 898 × 423; 288 KB
Unless high blood levels of uric acid are determined in a clinical laboratory, hyperuricemia may not cause noticeable symptoms in most people. [4] Development of gout – which is a painful, short-term disorder – is the most common consequence of hyperuricemia, which causes deposition of uric acid crystals usually in joints of the extremities, but may also induce formation of kidney stones ...
Uric acid displays lactam–lactim tautomerism. [4] Uric acid crystallizes in the lactam form, [5] with computational chemistry also indicating that tautomer to be the most stable. [6] Uric acid is a diprotic acid with pK a1 = 5.4 and pK a2 = 10.3. [7] At physiological pH, urate predominates in solution. [medical citation needed]
Purine is a heterocyclic aromatic organic compound that consists of two rings (pyrimidine and imidazole) fused together. It is water-soluble. Purine also gives its name to the wider class of molecules, purines, which include substituted purines and their tautomers. They are the most widely occurring nitrogen-containing heterocycles in nature. [1]
Hypouricemia or hypouricaemia is a level of uric acid in blood serum that is below normal. In humans, the normal range of this blood component has a lower threshold set variously in the range of 2 mg/dL to 4 mg/dL, while the upper threshold is 530 μmol/L (6 mg/dL) for women and 619 μmol/L (7 mg/dL) for men. [1]